Raymond Rosa
Overview
Explore the profile of Raymond Rosa including associated specialties, affiliations and a list of published articles.
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13
Citations
306
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Recent Articles
1.
Gao X, Sheng Y, Yu S, Li J, Rosa R, Girgis S, et al.
Pharm Res
. 2023 Mar;
40(5):1223-1238.
PMID: 36949370
Purpose: To evaluate how obesity affects the pharmacokinetics of human IgG following subcutaneous (SC) and intravenous (IV) administration to rats and the homeostasis of endogenous rat IgG. Methods: Differences in...
2.
Gao X, Voronin G, Generaux C, Rose A, Kozhich A, Dalglish G, et al.
Pharm Res
. 2020 Jul;
37(8):155.
PMID: 32720159
Purpose: The purpose of this work was to investigate the role of the lymphatic system in the pharmacokinetics of etanercept, a fusion protein. Methods: Etanercept 1 mg/kg was administered intravenously...
3.
Johns D, Wang S, Rosa R, Hubert J, Xu S, Chen Y, et al.
Pharmacol Res Perspect
. 2019 Dec;
7(6):e00543.
PMID: 31832204
Anacetrapib is an inhibitor of cholesteryl ester transfer protein (CETP) previously under development as a lipid-modifying agent that reduces LDL-cholesterol and increases HDL-cholesterol in hypercholesterolemic patients. Anacetrapib demonstrates a long...
4.
Hampton C, Rosa R, Szeto D, Forrest G, Campbell B, Kennan R, et al.
SAGE Open Med
. 2017 May;
5():2050312117700057.
PMID: 28491305
Introduction: Despite the widespread use of the mouse transverse aortic constriction heart failure model, there are no reports on the characterization of the standard-of-care agent carvedilol in this model. Methods:...
5.
Hampton C, Rosa R, Campbell B, Kennan R, Gichuru L, Ping X, et al.
J Pharmacol Toxicol Methods
. 2016 Dec;
84:93-101.
PMID: 27956205
Introduction: Mouse transverse aortic constriction (TAC) is a widely-used model of pressure overload-induced heart failure. An intrinsic limitation of the model is variability in the response to pressure overload even...
6.
McLaren D, Wang S, Stout S, Xie D, Miller P, Mendoza V, et al.
J Lipid Res
. 2012 Oct;
54(1):276-81.
PMID: 23042787
Isotopic tracers have been used to examine lipid trafficking for many years, and data from those studies have typically yielded novel insight regarding the pathophysiology of dyslipidemia. Previous experimental designs...
7.
Zhou H, Li W, Wang S, Mendoza V, Rosa R, Hubert J, et al.
J Lipid Res
. 2012 Mar;
53(6):1223-31.
PMID: 22389331
Stable isotope tracer studies of apoprotein flux in rodent models present difficulties as they require working with small volumes of plasma. We demonstrate the ability to measure apoprotein flux by...
8.
McLaren D, He T, Wang S, Mendoza V, Rosa R, Gagen K, et al.
J Lipid Res
. 2011 Mar;
52(6):1150-1161.
PMID: 21415123
The use of stable isotopically labeled substrates and analysis by mass spectrometry have provided substantial insight into rates of synthesis, disposition, and utilization of lipids in vivo. The information to...
9.
Sweis R, Hunt J, Sinclair P, Chen Y, Eveland S, Guo Q, et al.
Bioorg Med Chem Lett
. 2011 Mar;
21(9):2597-600.
PMID: 21398121
The development of 2-phenylbenzoxazoles as inhibitors of cholesteryl ester transfer protein (CETP) is described. Efforts focused on finding suitable replacements for the central piperidine with the aim of reducing hERG...
10.
Sweis R, Hunt J, Kallashi F, Hammond M, Chen Y, Eveland S, et al.
Bioorg Med Chem Lett
. 2010 Dec;
21(6):1890-5.
PMID: 21147531
The development of 2-phenylbenzoxazoles as inhibitors of cholesteryl ester transfer protein (CETP) is described. Initial efforts aimed at engineering replacements for the aniline substructures in the benchmark molecule. Reversing the...