Raymond C Koehler
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Explore the profile of Raymond C Koehler including associated specialties, affiliations and a list of published articles.
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161
Citations
4169
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Recent Articles
1.
Radabaugh H, Harris N, Wanner I, Burns M, McCabe J, Korotcov A, et al.
J Neurotrauma
. 2025 Jan;
PMID: 39841551
Traumatic brain injury (TBI) has long been a leading cause of death and disability, yet research has failed to successfully translate findings from the pre-clinical, animal setting into the clinic....
2.
Wanner I, McCabe J, Huie J, Harris N, Paydar A, McMann-Chapman C, et al.
J Neurotrauma
. 2025 Jan;
PMID: 39831841
Effective team science requires procedural harmonization for rigor and reproducibility. Multicenter studies across experimental modalities (domains) can help accelerate translation. The Translational Outcomes Project in NeuroTrauma (TOP-NT) is a pre-clinical...
3.
Morais A, Imai T, Jin X, Locascio J, Boisserand L, Herman A, et al.
Circ Res
. 2024 Jul;
135(5):575-592.
PMID: 39034919
Background: The SPAN trial (Stroke Preclinical Assessment Network) is the largest preclinical study testing acute stroke interventions in experimental focal cerebral ischemia using endovascular filament middle cerebral artery occlusion (MCAo)....
4.
Sorcher J, Santos P, Adams S, Kulikowicz E, Vaidya D, Lee J, et al.
Pediatr Res
. 2024 Jul;
PMID: 39009765
Background: Diastolic blood pressure (DBP) is suggested as a surrogate for coronary perfusion pressure (CPP) during cardiopulmonary resuscitation. We examined the correlation between DBP and CPP and hypothesized that both...
5.
Yang Z, Hopkins C, Santos P, Adams S, Kulikowicz E, Lee J, et al.
Am J Physiol Regul Integr Comp Physiol
. 2024 Jun;
327(3):R304-R318.
PMID: 38860282
Clinical trials of hypothermia after pediatric cardiac arrest (CA) have not seen robust improvement in functional outcome, possibly because of the long delay in achieving target temperature. Previous work in...
6.
Kim J, Lee R, Yazigi E, Atta L, Feghali J, Pant A, et al.
Brain Behav Immun
. 2023 Dec;
116:160-174.
PMID: 38070624
Acute cerebral ischemia triggers a profound inflammatory response. While macrophages polarized to an M2-like phenotype clear debris and facilitate tissue repair, aberrant or prolonged macrophage activation is counterproductive to recovery....
7.
Primiani C, Lee J, OBrien C, Chen M, Perin J, Kulikowicz E, et al.
Cells
. 2023 Oct;
12(20).
PMID: 37887298
The effects of hypothermia on neonatal encephalopathy may vary topographically and cytopathologically in the neocortex with manifestations potentially influenced by seizures that alter the severity, distribution, and type of neuropathology....
8.
Lyden P, Diniz M, Bosetti F, Lamb J, Nagarkatti K, Rogatko A, et al.
Sci Transl Med
. 2023 Sep;
15(714):eadg8656.
PMID: 37729432
Human diseases may be modeled in animals to allow preclinical assessment of putative new clinical interventions. Recent, highly publicized failures of large clinical trials called into question the rigor, design,...
9.
Han R, Lan X, Han Z, Ren H, Aafreen S, Wang W, et al.
Biomaterials
. 2023 Aug;
301:122277.
PMID: 37597297
Intracerebral hemorrhage (ICH) remains the most lethal type of stroke, and effective clinical therapies that can speed up hematoma resolution after ICH are still lacking. While the beneficial effects of...
10.
Koehler R, Reyes M, Hopkins C, Armstrong J, Cao S, Kulikowicz E, et al.
J Cereb Blood Flow Metab
. 2023 Jul;
43(11):1842-1856.
PMID: 37466218
Neurologic outcome from out-of-hospital pediatric cardiac arrest remains poor. Although therapeutic hypothermia has been attempted in this patient population, a beneficial effect has yet to be demonstrated, possibly because of...