Ray A Olsson
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Explore the profile of Ray A Olsson including associated specialties, affiliations and a list of published articles.
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18
Citations
183
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Recent Articles
11.
Figler H, Olsson R, Linden J
Mol Pharmacol
. 2003 Dec;
64(6):1557-64.
PMID: 14645687
Endogenous ligands of G protein-coupled receptors bind to orthosteric sites that are topologically distinct from allosteric sites. Certain aminothiophenes such as (2-amino-4,5-dimethyl-3-thienyl)-[3-(trifluromethyl)-phenyl]-methanone (PD81,723) and 2-amino-4,5,6,7-tetrahydro-benzo[b]thiophen-3-yl)-biphenyl-4-yl-methanone (ATL525) are positive allosteric regulators,...
12.
Bauer A, Holschbach M, Cremer M, Weber S, Boy C, Jon Shah N, et al.
J Nucl Med
. 2003 Oct;
44(10):1682-9.
PMID: 14530487
Unlabelled: Adenosine modulates brain activity through 4 G protein-coupled receptors, primarily adenosine A(1) receptors (A(1)ARs). A(1)ARs are heterogeneously distributed throughout the brain and participate in many physiologic processes-for example, the...
13.
Bauer A, Holschbach M, Meyer P, Boy C, Herzog H, Olsson R, et al.
Neuroimage
. 2003 Sep;
19(4):1760-9.
PMID: 12948730
The important roles played by the A(1) adenosine receptor (A(1)AR) in brain physiology and pathology make this receptor a target for in vivo imaging. Here we describe the distribution of...
14.
Lutjens H, Zickgraf A, Figler H, Linden J, Olsson R, Scammells P
J Med Chem
. 2003 May;
46(10):1870-7.
PMID: 12723950
2-Amino-3-aroylthiophenes are agonist allosteric enhancers (AE) at the A(1) adenosine receptor (A(1)AR). Here we report the syntheses of three kinds of novel 2-aminothiophenes and assays of their AE activity at...
15.
Holschbach M, Olsson R, Bier D, Wutz W, Sihver W, Schuller M, et al.
J Med Chem
. 2002 Nov;
45(23):5150-6.
PMID: 12408725
This report describes the precursor synthesis and the no-carrier-added (nca) radiosynthesis of the new A(1) adenosine receptor (A(1)AR) antagonist [(18)F]8-cyclopentyl-3-(3-fluoropropyl)-1-propylxanthine (CPFPX), 3, with fluorine-18 (half-life = 109.6 min). Nucleophilic radiofluorination...
16.
Holschbach M, Olsson R
Curr Pharm Des
. 2002 Oct;
8(26):2345-52.
PMID: 12369949
In the last decade the field of purinergic pharmacology has continued to grow as the complexity of the receptor families and the various enzymes involved in purine metabolism have been...
17.
Chordia M, Murphree L, Macdonald T, Linden J, Olsson R
Bioorg Med Chem Lett
. 2002 Jun;
12(12):1563-6.
PMID: 12039562
This report describes the synthesis and structure-activity relationships of a new class of A(1) adenosine receptor agonist allosteric enhancers, 2-aminothiazolium salts. The EC(50) of compounds 6a, 6b, 7, and 8...
18.
Tranberg C, Zickgraf A, Giunta B, Luetjens H, Figler H, Murphree L, et al.
J Med Chem
. 2002 Jan;
45(2):382-9.
PMID: 11784142
2-Amino-3-benzoylthiophenes are allosteric enhancers (AE) of agonist activity at the A(1) adenosine receptor. The present report describes syntheses and assays of the AE activity at the human A(1)AR (hA(1)AR) of...