Ravi Nargund
Overview
Explore the profile of Ravi Nargund including associated specialties, affiliations and a list of published articles.
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Articles
20
Citations
177
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Recent Articles
1.
Nargund R, Wyvratt M, Lin S, Sebhat I, Greenlee W
J Med Chem
. 2023 Nov;
66(23):15567-15575.
PMID: 38032081
No abstract available.
2.
Palani A, Nawrocki A, Orvieto F, Bianchi E, Mandic E, Pessi A, et al.
ACS Med Chem Lett
. 2022 Aug;
13(8):1248-1254.
PMID: 35978682
Peptide-based analogues of the gut-derived incretin hormone, glucagon-like peptide 1 (GLP1), stimulate insulin secretion in a glucose-dependent manner. Currently marketed GLP1 receptor (GLP1R) agonists are safe and effective in the...
3.
Xu G, Liu Z, Wang X, Lu T, DesJarlais R, Thieu T, et al.
J Med Chem
. 2022 Jul;
65(15):10419-10440.
PMID: 35862732
Activated factor XI (FXIa) inhibitors are promising novel anticoagulants with low bleeding risk compared with current anticoagulants. The discovery of potent FXIa inhibitors with good oral bioavailability has been challenging....
4.
Xiao D, Dai X, Liu H, He S, Shi Z, Ludmerer S, et al.
Bioorg Med Chem Lett
. 2020 Feb;
30(7):127004.
PMID: 32061500
In a lead optimization effort towards NS5B NNI inhibitors, two multi-step parallel libraries were designed and successfully synthesized. Through this effort we discovered compound 9B, which achieved rigorous and delicate...
5.
Pio B, Chobanian H, Guo Y, Josien H, Hagmann W, Miller M, et al.
Bioorg Med Chem Lett
. 2019 May;
29(14):1842-1848.
PMID: 31109791
GPR40 (FFAR1 or FFA1) is a G protein-coupled receptor, primarily expressed in pancreatic islet β-cells and intestinal enteroendocrine cells. When activated by fatty acids, GPR40 elicits increased insulin secretion from...
6.
Huang X, Brubaker J, Zhou W, Biju P, Xiao L, Shao N, et al.
ACS Med Chem Lett
. 2018 Jul;
9(7):679-684.
PMID: 30034600
A novel series of tricyclic tetrahydroquinolines were identified as potent and selective CRTh2 receptor antagonists. The agonism and antagonism switch was achieved through structure-based drug design (SBDD) using a CRTh2...
7.
Moore M, Kelley D, Camacho R, Zafian P, Ye T, Lin S, et al.
Diabetes
. 2018 Mar;
67(6):1173-1181.
PMID: 29540491
We evaluated the hepatic and nonhepatic responses to glucose-responsive insulin (GRI). Eight dogs received GRI or regular human insulin (HI) in random order. A primed, continuous intravenous infusion of [3-H]glucose...
8.
Huang X, Rao A, Zhou W, Aslanian R, Nargund R, Buevich A, et al.
Bioorg Med Chem Lett
. 2017 Nov;
27(23):5344-5348.
PMID: 29110986
New synthetic methods were developed for the preparation of 2,3,6-trisubstituted 1-oxo-1,2-dihydroisoquinolines as CRTh antagonists. The isoquinolinone core could be constructed before the introduction of substitution groups or synthesized through a...
9.
Cernak T, Gesmundo N, Dykstra K, Yu Y, Wu Z, Shi Z, et al.
J Med Chem
. 2017 Mar;
60(9):3594-3605.
PMID: 28252959
Miniaturization and parallel processing play an important role in the evolution of many technologies. We demonstrate the application of miniaturized high-throughput experimentation methods to resolve synthetic chemistry challenges on the...
10.
Scott J, DeMong D, Greshock T, Basu K, Dai X, Harris J, et al.
J Med Chem
. 2017 Mar;
60(7):2983-2992.
PMID: 28245354
Leucine-rich repeat kinase 2 (LRRK2) is a large, multidomain protein which contains a kinase domain and GTPase domain among other regions. Individuals possessing gain of function mutations in the kinase...