Anandan Palani
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Explore the profile of Anandan Palani including associated specialties, affiliations and a list of published articles.
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55
Citations
391
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Recent Articles
1.
Ma X, Sloman D, Duggal R, Anderson K, Ballard J, Bharathan I, et al.
J Med Chem
. 2024 Jun;
67(13):11024-11052.
PMID: 38924388
Oncogenic mutations in the gene account for 30% of all human tumors; more than 60% of which present as KRAS mutations at the hotspot codon 12. After decades of intense...
2.
Huang C, Palani A, Yang Z, Deng Q, Reddy V, Nargund R, et al.
ACS Med Chem Lett
. 2022 Aug;
13(8):1255-1261.
PMID: 35978702
The combination of insulin and incretin-based therapies has emerged as a potential promising tactic for the treatment of diabetes. Here we report the first example of a unimolecular triagonist to...
3.
Palani A, Nawrocki A, Orvieto F, Bianchi E, Mandic E, Pessi A, et al.
ACS Med Chem Lett
. 2022 Aug;
13(8):1248-1254.
PMID: 35978682
Peptide-based analogues of the gut-derived incretin hormone, glucagon-like peptide 1 (GLP1), stimulate insulin secretion in a glucose-dependent manner. Currently marketed GLP1 receptor (GLP1R) agonists are safe and effective in the...
4.
Adams G, Pall P, Grauer S, Zhou X, Ballard J, Vavrek M, et al.
J Med Chem
. 2021 Dec;
65(1):485-496.
PMID: 34931831
Inhibitor cystine knot peptides, derived from venom, have evolved to block ion channel function but are often toxic when dosed at pharmacologically relevant levels . The article describes the design...
5.
Li D, Zhang H, Lyons T, Lu M, Achab A, Pu Q, et al.
ACS Med Chem Lett
. 2021 Nov;
12(11):1678-1688.
PMID: 34795856
Comprehensive synthetic strategies afforded a diverse set of structurally unique bicyclic proline-containing arginase inhibitors with a high degree of three-dimensionality. The analogs that favored the Cγ-exo conformation of the proline...
6.
Lu M, Zhang H, Li D, Childers M, Pu Q, Palte R, et al.
ACS Med Chem Lett
. 2021 Sep;
12(9):1380-1388.
PMID: 34527178
Recent data suggest that the inhibition of arginase (ARG) has therapeutic potential for the treatment of a number of indications ranging from pulmonary and vascular disease to cancer. Thus, high...
7.
Mandal M, Buevich A, Caldwell J, Hyde L, Huang X, Liu X, et al.
J Med Chem
. 2020 Aug;
63(15):8216-8230.
PMID: 32786237
Herein, we disclose three structurally differentiated γ-secretase modulators (GSMs) based on an oxadiazine scaffold. The analogues from series I potently inhibit the generation of Aβ in vitro when the substituents...
8.
Mitcheltree M, Li D, Achab A, Beard A, Chakravarthy K, Cheng M, et al.
ACS Med Chem Lett
. 2020 Apr;
11(4):582-588.
PMID: 32292567
The action of arginase, a metalloenzyme responsible for the hydrolysis of arginine to urea and ornithine, is hypothesized to suppress immune-cell activity within the tumor microenvironment, and thus its inhibition...
9.
Xiao D, Dai X, Liu H, He S, Shi Z, Ludmerer S, et al.
Bioorg Med Chem Lett
. 2020 Feb;
30(7):127004.
PMID: 32061500
In a lead optimization effort towards NS5B NNI inhibitors, two multi-step parallel libraries were designed and successfully synthesized. Through this effort we discovered compound 9B, which achieved rigorous and delicate...
10.
Liu H, Dai X, He S, Brockunier L, Marcantonio K, Ludmerer S, et al.
Bioorg Med Chem Lett
. 2018 Nov;
29(24):126104.
PMID: 30389294
Hepatitis C virus (HCV) NS5B polymerase is a prime target for the development of direct-acting antiviral drugs for the treatment of chronic HCV infection. Several novel and potent HCV NS5B...