Ravi Manjithaya
Overview
Explore the profile of Ravi Manjithaya including associated specialties, affiliations and a list of published articles.
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56
Citations
2507
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Recent Articles
1.
Raghavan A, Kashyap R, Sreedevi P, Jos S, Chatterjee S, Alex A, et al.
iScience
. 2024 Aug;
27(8):110565.
PMID: 39184442
Astroglia play crucial neuroprotective roles by internalizing pathogenic aggregates and facilitating their degradation. Here, we show that α-SYN protofibril-induced organelle toxicities and reactive oxygen species (ROS) cause premature cellular senescence...
2.
Bhat M, Nambiar A, Edakkandiyil L, Abraham I, Sen R, Negi M, et al.
Mol Biol Cell
. 2024 Jun;
35(8):mr6.
PMID: 38888935
Maintenance of a pool of active lysosomes with acidic pH and degradative hydrolases is crucial for cell health. Abnormalities in lysosomal function are closely linked to diseases, such as lysosomal...
3.
Chakravorty A, Sheeba V, Manjithaya R
Methods Mol Biol
. 2024 Mar;
2761:97-120.
PMID: 38427233
Neuronal synapse dysfunction is a key characteristic of several neurodegenerative disorders, such as Alzheimer's disease, spinocerebellar ataxias, and Huntington's disease. Modeling these disorders to study synaptic dysfunction requires a robust...
4.
Sen R, Jetto C, Manjithaya R
J Biosci
. 2024 Feb;
49.
PMID: 38383977
Mitochondrial DNA depletion syndromes (MDS) encompass a wide spectrum of rare genetic disorders caused by severe reduction in mitochondrial DNA (mtDNA), and exhibit heterogenous phenotypes classified as myopathic, encephalomyopathic, hepatocerebral,...
5.
Nambiar A, Manjithaya R
J Cell Sci
. 2024 Feb;
137(3).
PMID: 38329417
Most of the vesicular transport pathways inside the cell are facilitated by molecular motors that move along cytoskeletal networks. Autophagy is a well-explored catabolic pathway that is initiated by the...
6.
Pant A, Yao X, Lavedrine A, Viret C, Dockterman J, Chauhan S, et al.
Autophagy Rep
. 2023 Jul;
1(1):438-515.
PMID: 37425656
Autophagy is a highly conserved process that utilizes lysosomes to selectively degrade a variety of intracellular cargo, thus providing quality control over cellular components and maintaining cellular regulatory functions. Autophagy...
7.
Padmanabhan S, Manjithaya R
Front Mol Neurosci
. 2023 Jul;
16:983108.
PMID: 37396786
Neurodegenerative disease-causing proteins such as alpha-synuclein, tau, and huntingtin are known to traverse across cells via exosomes, extracellular vesicles and tunneling nanotubes (TNTs). There seems to be good synergy between...
8.
Sharma A, Narasimha K, Manjithaya R, Sheeba V
J Neurosci
. 2023 Jun;
43(26):4907-4925.
PMID: 37268416
Circadian and sleep defects are well documented in Huntington's disease (HD). Modulation of the autophagy pathway has been shown to mitigate toxic effects of mutant Huntingtin (HTT) protein. However, it...
9.
Keerti , Pant A, Manjithaya R
J Cell Sci
. 2023 May;
134(15).
PMID: 37248958
The existence of constantly evolving dynamic interactions between the host and the pathogen determines their fate in this continuous arms race. Hence, identifying the molecular basis of processes that reinforce...
10.
Kataura T, Sedlackova L, Otten E, Kumari R, Shapira D, Scialo F, et al.
Dev Cell
. 2022 Nov;
57(22):2584-2598.e11.
PMID: 36413951
Autophagy is an essential catabolic process that promotes the clearance of surplus or damaged intracellular components. Loss of autophagy in age-related human pathologies contributes to tissue degeneration through a poorly...