James P Clement
Overview
Explore the profile of James P Clement including associated specialties, affiliations and a list of published articles.
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25
Citations
581
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Recent Articles
1.
Singh A, Joshi I, Reddy N, Purushotham S, Eswaramoorthy M, Vasudevan M, et al.
Aging Cell
. 2025 Jan;
24(3):e14408.
PMID: 39878322
SYNGAP1 is a Ras GTPase-activating protein that plays a crucial role during brain development and in synaptic plasticity. Sporadic heterozygous mutations in SYNGAP1 affect social and emotional behaviour observed in...
2.
Thumu S, Jain M, Soman S, Das S, Verma V, Nandi A, et al.
Elife
. 2024 Jul;
13.
PMID: 38949864
No abstract available.
3.
Singh A, Rai A, Joshi I, Reddy D, Guha R, Alka K, et al.
ACS Chem Neurosci
. 2024 May;
15(15):2741-2755.
PMID: 38795032
TTK21 is a small-molecule activator of p300/creb binding protein (CBP) acetyltransferase activity, which, upon conjugation with a glucose-derived carbon nanosphere (CSP), can efficiently cross the blood-brain barrier and activate histone...
4.
Thumu S, Jain M, Soman S, Das S, Verma V, Nandi A, et al.
Elife
. 2024 Jan;
13.
PMID: 38289036
Reactive astrogliosis is a common pathological hallmark of CNS injury, infection, and neurodegeneration, where reactive astrocytes can be protective or detrimental to normal brain functions. Currently, the mechanisms regulating neuroprotective...
5.
Chakraborty S, Parayil R, Mishra S, Nongthomba U, Clement J
Int J Mol Sci
. 2022 Sep;
23(18).
PMID: 36142719
Epilepsy, a heterogeneous group of brain-related diseases, has continued to significantly burden society and families. Epilepsy comorbid with neurodevelopmental disorders (NDDs) is believed to occur due to multifaceted pathophysiological mechanisms...
6.
Purushotham S, Reddy N, DSouza M, Roy Choudhury N, Ganguly A, Gopalakrishna N, et al.
Exp Brain Res
. 2022 Sep;
240(10):2525-2567.
PMID: 36063192
Intellectual disability (ID) and autism spectrum disorder (ASD) are neurodevelopmental disorders that have become a primary clinical and social concern, with a prevalence of 2-3% in the population. Neuronal function...
7.
Srinivasan B, Samaddar S, Mylavarapu S, Clement J, Banerjee S
PLoS Biol
. 2021 Nov;
19(11):e3001432.
PMID: 34813590
Homeostatic scaling in neurons has been attributed to the individual contribution of either translation or degradation; however, there remains limited insight toward understanding how the interplay between the two processes...
8.
Verma V, Vijay Kumar M, Sharma K, Rajaram S, Muddashetty R, Manjithaya R, et al.
Exp Brain Res
. 2021 Nov;
240(1):289-309.
PMID: 34739555
Haploinsufficiency in SYNGAP1 is implicated in intellectual disability (ID) and autism spectrum disorder (ASD) and affects the maturation of dendritic spines. The abnormal spine development has been suggested to cause...
9.
Verma V, Mandora A, Botre A, Clement J
Mol Biol Rep
. 2021 Aug;
48(9):6663.
PMID: 34431039
No abstract available.
10.
Chakraborty R, Vijay Kumar M, Clement J
Neurobiol Learn Mem
. 2021 Mar;
180:107415.
PMID: 33647449
Organisms have the unique ability to adapt to their environment by making use of external inputs. In the process, the brain is shaped by experiences that go hand-in-hand with optimisation...