Rapolas Spalinskas
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Explore the profile of Rapolas Spalinskas including associated specialties, affiliations and a list of published articles.
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10
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107
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Recent Articles
1.
Zhigulev A, Norberg Z, Cordier J, Spalinskas R, Bassereh H, Bjorn N, et al.
Life Sci Alliance
. 2024 Jan;
7(3).
PMID: 38228368
Non-small cell lung cancer is often diagnosed at advanced stages, and many patients are still treated with classical chemotherapy. The unselective nature of chemotherapy often results in severe myelosuppression. Previous...
2.
Sahlen P, Spalinskas R, Asad S, Mahapatra K, Hojer P, Anil A, et al.
J Allergy Clin Immunol
. 2020 Oct;
147(5):1742-1752.
PMID: 33069716
Background: Hundreds of variants associated with atopic dermatitis (AD) and psoriasis, 2 common inflammatory skin disorders, have previously been discovered through genome-wide association studies (GWASs). The majority of these variants...
3.
Bjorn N, Badam T, Spalinskas R, Branden E, Koyi H, Lewensohn R, et al.
NPJ Syst Biol Appl
. 2020 Aug;
6(1):25.
PMID: 32839457
Gemcitabine/carboplatin chemotherapy commonly induces myelosuppression, including neutropenia, leukopenia, and thrombocytopenia. Predicting patients at risk of these adverse drug reactions (ADRs) and adjusting treatments accordingly is a long-term goal of personalized...
4.
Pradhananga S, Spalinskas R, Poujade F, Eriksson P, Sahlen P
Cell Immunol
. 2020 Jun;
355:104148.
PMID: 32592980
Macrophages are highly plastic immune cells with temporally distinct transcriptome changes upon lipopolysaccride (LPS) activation. However, to what extent transcriptome reprogramming is mediated via spatial chromatin looping is not well...
5.
Cavalli M, Diamanti K, Pan G, Spalinskas R, Kumar C, Deshmukh A, et al.
OMICS
. 2020 Mar;
24(4):180-194.
PMID: 32181701
The liver is the largest solid organ and a primary metabolic hub. In recent years, intact cell nuclei were used to perform single-nuclei RNA-seq (snRNA-seq) for tissues difficult to dissociate...
6.
Cavalli M, Baltzer N, Umer H, Grau J, Lemnian I, Pan G, et al.
Sci Rep
. 2019 Feb;
9(1):2695.
PMID: 30804403
Several Genome Wide Association Studies (GWAS) have reported variants associated to immune diseases. However, the identified variants are rarely the drivers of the associations and the molecular mechanisms behind the...
7.
Akerborg O, Spalinskas R, Pradhananga S, Anil A, Hojer P, Poujade F, et al.
Circ Genom Precis Med
. 2019 Feb;
12(3):e002353.
PMID: 30786239
Background: Genetic variant landscape of coronary artery disease is dominated by noncoding variants among which many occur within putative enhancers regulating the expression levels of relevant genes. It is crucial...
8.
Zhang W, Chronis C, Chen X, Zhang H, Spalinskas R, Pardo M, et al.
Cell Stem Cell
. 2019 Jan;
24(1):138-152.e8.
PMID: 30609396
BAF complexes are composed of different subunits with varying functional and developmental roles, although many subunits have not been examined in depth. Here we show that the Baf45 subunit Dpf2...
9.
Chen L, Ye Y, Dai H, Zhang H, Zhang X, Wu Q, et al.
Stem Cells Int
. 2018 Jul;
2018:9576959.
PMID: 30013601
Loss-of-function studies are critically important in gene functional analysis of model organisms and cells. However, conditional gene inactivation in diploid cells is difficult to achieve, as it involves laborious vector...
10.
Anil A, Spalinskas R, Akerborg O, Sahlen P
Bioinformatics
. 2018 Feb;
34(4):675-677.
PMID: 29444232
Summary: Folding of eukaryotic genomes within nuclear space enables physical and functional contacts between regions that are otherwise kilobases away in sequence space. Targeted chromosome conformation capture methods (T2C, chi-C...