Raphael Ruppert
Overview
Explore the profile of Raphael Ruppert including associated specialties, affiliations and a list of published articles.
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Articles
18
Citations
790
Followers
0
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Recent Articles
1.
Lehman S, Vreeland W, Blaszczyk A, Adams-Hall S, Ahuja S, Arnaout A, et al.
Hum Gene Ther
. 2024 Dec;
36(1-2):36-44.
PMID: 39723438
Recombinant adeno-associated virus (AAV) is one of the main viral vector-based gene therapy platforms. AAV is a virus consisting of a ≈25 nm diameter capsid with a ≈4.7 kb cargo...
2.
Heckel J, Martinez A, Elger C, Haindl M, Leiss M, Ruppert R, et al.
Mol Ther Methods Clin Dev
. 2023 Dec;
31:101148.
PMID: 38046198
Recombinant adeno-associated viruses (rAAVs) are promising gene delivery vectors in the emerging field of gene therapies. To ensure their consistent quality during manufacturing and process development, multiple analytical techniques have...
3.
Aebischer M, Bouvarel T, Barrozo E, Kochardt D, Elger C, Haindl M, et al.
Int J Mol Sci
. 2023 May;
24(10).
PMID: 37239849
The purity of the three capsid proteins that make up recombinant adeno-associated virus (rAAV) is considered a critical quality attribute of gene therapy products. As such, there is a clear...
4.
Gstottner C, Hutanu A, Boon S, Raducanu A, Richter K, Haindl M, et al.
Anal Chem
. 2023 May;
95(22):8478-8486.
PMID: 37219094
After decades of research, gene therapy products have reached market maturity in recent years. Recombinant adeno-associated viruses (rAAVs) are one of the most promising gene delivery vehicles and are currently...
5.
Aebischer M, Gizardin-Fredon H, Lardeux H, Kochardt D, Elger C, Haindl M, et al.
Int J Mol Sci
. 2022 Oct;
23(20).
PMID: 36293189
Gene therapy is opening unprecedented opportunities for novel therapeutic approaches. Based on the concept of rescuing function mutations by co-expressing the correct gene to allow biological functions to be restored,...
6.
Harzschel A, Li L, Krenn P, Szenes-Nagy E, Andrieux G, Bayer E, et al.
J Leukoc Biol
. 2021 Dec;
111(4):745-758.
PMID: 34888947
Integrin-mediated interactions between hematopoietic cells and their microenvironment are important for the development and function of immune cells. Here, the role of the integrin adaptor Kindlin-3 in B cell homeostasis...
7.
Moretti F, Klapproth S, Ruppert R, Margraf A, Weber J, Pick R, et al.
Elife
. 2018 Sep;
7.
PMID: 30187863
The role of integrin-mediated adhesion during T cell progenitor homing to and differentiation within the thymus is ill-defined, mainly due to functional overlap. To circumvent compensation, we disrupted the hematopoietic...
8.
Rognoni E, Ruppert R, Fassler R
J Cell Sci
. 2016 Jan;
129(1):17-27.
PMID: 26729028
The kindlin (or fermitin) family of proteins comprises three members (kindlin-1,-2 and -3) of evolutionarily conserved focal adhesion (FA) proteins, whose best-known task is to increase integrin affinity for a...
9.
Klapproth S, Moretti F, Zeiler M, Ruppert R, Breithaupt U, Mueller S, et al.
Blood
. 2015 Oct;
126(24):2592-600.
PMID: 26438512
Hematopoietic cells depend on integrin-mediated adhesion and signaling, which is induced by kindlin-3 and talin-1. To determine whether platelet and polymorphonuclear neutrophil (PMN) functions require specific thresholds of kindlin-3, we...
10.
Ruppert R, Moser M, Sperandio M, Rognoni E, Orban M, Liu W, et al.
J Exp Med
. 2015 Aug;
212(9):1415-32.
PMID: 26282877
Hematopoietic stem cells (HSCs) generate highly dividing hematopoietic progenitor cells (HPCs), which produce all blood cell lineages. HSCs are usually quiescent, retained by integrins in specific niches, and become activated...