Sarah Klapproth
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Explore the profile of Sarah Klapproth including associated specialties, affiliations and a list of published articles.
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Articles
18
Citations
367
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0
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Recent Articles
1.
Geyer M, Geyer F, Reuning U, Klapproth S, Wolff K, Nieberler M
Head Face Med
. 2024 Jun;
20(1):37.
PMID: 38890650
Background: The treatment of oral squamous cell carcinoma (OSCC) remains challenging and survival rates have not been improved significantly over the past decades. Integrins have been recognized driving the cancer...
2.
Geyer F, Geyer M, Reuning U, Klapproth S, Wolff K, Nieberler M
Sci Rep
. 2024 Apr;
14(1):8286.
PMID: 38594331
Despite great efforts in improving existing therapies, the outcome of patients with advanced radioresistant HPV-negative head and neck squamous cell carcinoma (HNSCC) remains poor. The chromatin remodeler Chromodomain helicase DNA...
3.
Geyer F, Geyer M, Klapproth S, Wolff K, Nieberler M
STAR Protoc
. 2023 Jul;
4(3):102366.
PMID: 37421616
CRISPR-Cas9 is a powerful technology for accurate and optimizable genome editing. Here, we present a protocol for generating monoclonal knockout (KO) cell lines using CRISPR-Cas9, ribonucleoprotein complexes (RNPs), and lipofection...
4.
Bashiri Dezfouli A, Yazdi M, Benmebarek M, Schwab M, Michaelides S, Micciche A, et al.
Front Immunol
. 2022 Jun;
13:883694.
PMID: 35720311
Strategies to boost anti-tumor immunity are urgently needed to treat therapy-resistant late-stage cancers, including colorectal cancers (CRCs). Cytokine stimulation and genetic modifications with chimeric antigen receptors (CAR) represent promising strategies...
5.
Bromberger T, Klapproth S, Sperandio M, Moser M
Cells
. 2022 May;
11(9).
PMID: 35563841
The use of cell-based reporter systems has provided valuable insights into the molecular mechanisms of integrin activation. However, current models have significant drawbacks because their artificially expressed integrins cannot be...
6.
Klapproth S, Richter K, Turk C, Bock T, Bromberger T, Dominik J, et al.
J Cell Sci
. 2021 Oct;
134(22).
PMID: 34704600
Osteoclasts form special integrin-mediated adhesion structures called sealing zones that enable them to adhere to and resorb bone. Sealing zones consist of densely packed podosomes tightly interconnected by actin fibers....
7.
Bromberger T, Klapproth S, Rohwedder I, Weber J, Pick R, Mittmann L, et al.
Front Immunol
. 2021 Sep;
12:702345.
PMID: 34489950
β2 integrins mediate key processes during leukocyte trafficking. Upon leukocyte activation, the structurally bent β2 integrins change their conformation towards an extended, intermediate and eventually high affinity conformation, which mediate...
8.
Rohwedder I, Kurz A, Pruenster M, Immler R, Pick R, Eggersmann T, et al.
Haematologica
. 2019 Nov;
105(7):1845-1856.
PMID: 31699792
Leukocyte recruitment into inflamed tissue is highly dependent on the activation and binding of integrins to their respective ligands, followed by the induction of various signaling events within the cell...
9.
Bromberger T, Zhu L, Klapproth S, Qin J, Moser M
J Cell Sci
. 2019 Oct;
132(21).
PMID: 31578239
Recruitment and tethering of talin to the plasma membrane initiate the process of integrin activation. Multiple factors including the Rap1 proteins, RIAM (also known as APBB1IP) and PIP bind talin...
10.
Klapproth S, Bromberger T, Turk C, Kruger M, Moser M
J Cell Biol
. 2019 Sep;
218(10):3436-3454.
PMID: 31537712
Binding of kindlins to integrins is required for integrin activation, stable ligand binding, and subsequent intracellular signaling. How hematopoietic kindlin-3 contributes to the assembly and stability of the adhesion complex...