Raphael Ceccaldi
Overview
Explore the profile of Raphael Ceccaldi including associated specialties, affiliations and a list of published articles.
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Articles
21
Citations
3157
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0
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Recent Articles
1.
Musiani D, Yucel H, Vallette M, Angrisani A, El Botty R, Ouine B, et al.
Mol Cell
. 2025 Feb;
PMID: 40010343
Resistance to poly (ADP-ribose) polymerase (PARP) inhibitors (PARPis) is the major obstacle to their effectiveness in the treatment of homologous recombination (HR)-deficient (HRD) tumors. Hence, developing alternative treatments for HRD...
2.
Gelot C, Kovacs M, Miron S, Mylne E, Haan A, Boeffard-Dosierre L, et al.
Nature
. 2024 Jan;
626(7999):E13.
PMID: 38273133
No abstract available.
3.
Kovacs M, Vallette M, Wiertsema P, Dingli F, Loew D, Nader G, et al.
Mol Cell
. 2023 Oct;
83(20):3659-3668.e10.
PMID: 37832547
The integrity of the nuclear envelope (NE) is essential for maintaining the structural stability of the nucleus. Rupture of the NE has been frequently observed in cancer cells, especially in...
4.
Gelot C, Kovacs M, Miron S, Mylne E, Haan A, Boeffard-Dosierre L, et al.
Nature
. 2023 Sep;
621(7978):415-422.
PMID: 37674080
DNA double-strand breaks (DSBs) are deleterious lesions that challenge genome integrity. To mitigate this threat, human cells rely on the activity of multiple DNA repair machineries that are tightly regulated...
5.
Berrada S, Martinez-Balsalobre E, Larcher L, Azzoni V, Vasquez N, Da Costa M, et al.
Nucleic Acids Res
. 2023 Jul;
51(15):7988-8004.
PMID: 37395445
Fanconi anemia (FA) is a genetic disorder associated with developmental defects, bone marrow failure and cancer. The FA pathway is crucial for the repair of DNA interstrand crosslinks (ICLs). In...
6.
Zhou J, Gelot C, Pantelidou C, Li A, Yucel H, Davis R, et al.
Nat Cancer
. 2021 Jun;
2(6):598-610.
PMID: 34179826
DNA polymerase theta (POLθ) is synthetic lethal with Homologous Recombination (HR) deficiency and thus a candidate target for HR-deficient cancers. Through high-throughput small molecule screens we identified the antibiotic Novobiocin...
7.
Przetocka S, Porro A, Bolck H, Walker C, Lezaja A, Trenner A, et al.
Mol Cell
. 2018 Oct;
72(3):568-582.e6.
PMID: 30344097
Protecting stalled DNA replication forks from degradation by promiscuous nucleases is essential to prevent genomic instability, a major driving force of tumorigenesis. Several proteins commonly associated with the repair of...
8.
Rondinelli B, Gogola E, Yucel H, Duarte A, van de Ven M, van der Sluijs R, et al.
Nat Cell Biol
. 2017 Oct;
19(11):1371-1378.
PMID: 29035360
The emergence of resistance to poly-ADP-ribose polymerase inhibitors (PARPi) poses a threat to the treatment of BRCA1 and BRCA2 (BRCA1/2)-deficient tumours. Stabilization of stalled DNA replication forks is a recently...
9.
Bluteau D, Masliah-Planchon J, Clairmont C, Rousseau A, Ceccaldi R, Dubois dEnghien C, et al.
J Clin Invest
. 2017 Mar;
127(3):1117.
PMID: 28248207
No abstract available.
10.
Bluteau D, Masliah-Planchon J, Clairmont C, Rousseau A, Ceccaldi R, Dubois dEnghien C, et al.
J Clin Invest
. 2016 Aug;
126(9):3580-4.
PMID: 27500492
Fanconi anemia (FA) is a recessive genetic disease characterized by congenital abnormalities, chromosome instability, progressive bone marrow failure (BMF), and a strong predisposition to cancer. Twenty FA genes have been...