Ranjith P Anand
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Explore the profile of Ranjith P Anand including associated specialties, affiliations and a list of published articles.
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12
Citations
546
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Recent Articles
1.
Kawai T, Williams W, Elias N, Fishman J, Crisalli K, Longchamp A, et al.
N Engl J Med
. 2025 Feb;
PMID: 39927618
Xenotransplantation offers a potential solution to the organ shortage crisis. A 62-year-old hemodialysis-dependent man with long-standing diabetes, advanced vasculopathy, and marked dialysis-access challenges received a gene-edited porcine kidney with 69...
2.
Anand R, Layer J, Heja D, Hirose T, Lassiter G, Firl D, et al.
Nature
. 2023 Oct;
622(7982):393-401.
PMID: 37821590
Recent human decedent model studies and compassionate xenograft use have explored the promise of porcine organs for human transplantation. To proceed to human studies, a clinically ready porcine donor must...
3.
Lemos B, Kaplan A, Bae J, Ferrazzoli A, Kuo J, Anand R, et al.
Proc Natl Acad Sci U S A
. 2018 Feb;
115(9):E2040-E2047.
PMID: 29440496
Harnessing CRISPR-Cas9 technology provides an unprecedented ability to modify genomic loci via DNA double-strand break (DSB) induction and repair. We analyzed nonhomologous end-joining (NHEJ) repair induced by Cas9 in budding...
4.
Nguyen J, Viterbo D, Anand R, Verra L, Sloan L, Richard G, et al.
Nucleic Acids Res
. 2017 Feb;
45(8):4519-4531.
PMID: 28175398
Trinucleotide repeats are a source of genome instability, causing replication fork stalling, chromosome fragility, and impaired repair. Specialized helicases play an important role in unwinding DNA structures to maintain genome...
5.
Yimit A, Kim T, Anand R, Meister S, Ou J, Haber J, et al.
Genetics
. 2016 Feb;
203(1):147-57.
PMID: 26920759
Double-strand DNA breaks occur upon exposure of cells to ionizing radiation and certain chemical agents or indirectly through replication fork collapse at DNA damage sites. If left unrepaired, double-strand breaks...
6.
Anand R, Tsaponina O, Greenwell P, Lee C, Du W, Petes T, et al.
Genes Dev
. 2014 Nov;
28(21):2394-406.
PMID: 25367035
Recent high-resolution genome analyses of cancer and other diseases have revealed the occurrence of microhomology-mediated chromosome rearrangements and copy number changes. Although some of these rearrangements appear to involve nonhomologous...
7.
Anand R, Lovett S, Haber J
Cold Spring Harb Perspect Biol
. 2013 Jul;
5(12):a010397.
PMID: 23881940
Recombination-dependent DNA replication, often called break-induced replication (BIR), was initially invoked to explain recombination events in bacteriophage but it has recently been recognized as a fundamentally important mechanism to repair...
8.
Mehrotra S, Ningappa M, Raman J, Anand R, Balaram H
Biochim Biophys Acta
. 2012 Feb;
1824(4):589-97.
PMID: 22289630
Plasmodium falciparum adenylosuccinate synthetase, a homodimeric enzyme, contains 10 cysteine residues per subunit. Among these, Cys250, Cys328 and Cys368 lie at the dimer interface and are not conserved across organisms....
9.
Anand R, Shah K, Niu H, Sung P, Mirkin S, Freudenreich C
Nucleic Acids Res
. 2011 Oct;
40(3):1091-105.
PMID: 21984413
DNA sequences that form secondary structures or bind protein complexes are known barriers to replication and potential inducers of genome instability. In order to determine which helicases facilitate DNA replication...
10.
Kerrest A, Anand R, Sundararajan R, Bermejo R, Liberi G, Dujon B, et al.
Nat Struct Mol Biol
. 2009 Jan;
16(2):159-67.
PMID: 19136956
Several molecular mechanisms have been proposed to explain trinucleotide repeat expansions. Here we show that in yeast srs2Delta cells, CTG repeats undergo both expansions and contractions, and they show increased...