Break-induced DNA Replication

Overview

Journal Cold Spring Harb Perspect Biol

Specialties Biology
Molecular Biology

Date 2013 Jul 25

PMID 23881940

Citations 147

Authors

Ranjith P Anand

Susan T Lovett

James E Haber

Affiliations

Soon will be listed here.

Abstract

Recombination-dependent DNA replication, often called break-induced replication (BIR), was initially invoked to explain recombination events in bacteriophage but it has recently been recognized as a fundamentally important mechanism to repair double-strand chromosome breaks in eukaryotes. This mechanism appears to be critically important in the restarting of stalled and broken replication forks and in maintaining the integrity of eroded telomeres. Although BIR helps preserve genome integrity during replication, it also promotes genome instability by the production of loss of heterozygosity and the formation of nonreciprocal translocations, as well as in the generation of complex chromosomal rearrangements.

Citing Articles

53BP1 deficiency leads to hyperrecombination using break-induced replication (BIR).

Shah S, Li Y, Li S, Hu Q, Wu T, Shi Y Nat Commun. 2024; 15(1):8648.

PMID: 39368985 PMC: 11455893. DOI: 10.1038/s41467-024-52916-z.

53BP1 deficiency leads to hyperrecombination using break-induced replication (BIR).

Shah S, Li Y, Li S, Hu Q, Wu T, Shi Y bioRxiv. 2024; .

PMID: 39314326 PMC: 11419065. DOI: 10.1101/2024.09.11.612483.

Polyubiquitinated PCNA triggers SLX4-mediated break-induced replication in alternative lengthening of telomeres (ALT) cancer cells.

Kim S, Park S, Kang N, Ra J, Myung K, Lee K Nucleic Acids Res. 2024; 52(19):11785-11805.

PMID: 39291733 PMC: 11514459. DOI: 10.1093/nar/gkae785.

Linear DNA-driven recombination in mammalian mitochondria.

Fragkoulis G, Hangas A, Fekete Z, Michell C, Moraes C, Willcox S Nucleic Acids Res. 2024; 52(6):3088-3105.

PMID: 38300793 PMC: 11014290. DOI: 10.1093/nar/gkae040.

MutSβ protects common fragile sites by facilitating homology-directed repair at DNA double-strand breaks with secondary structures.

Li Y, Zhang Y, Shah S, Chang C, Wang H, Wu X Nucleic Acids Res. 2023; 52(3):1120-1135.

PMID: 38038265 PMC: 10853791. DOI: 10.1093/nar/gkad1112.

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