Ranjani Varadan
Overview
Explore the profile of Ranjani Varadan including associated specialties, affiliations and a list of published articles.
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Articles
11
Citations
839
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Recent Articles
1.
Schumann F, Varadan R, Tayakuniyil P, Grossman J, Camarero J, Fushman D
Front Chem
. 2015 Apr;
3:26.
PMID: 25905098
Understanding of the effects of the backbone cyclization on the structure and dynamics of a protein is essential for using protein topology engineering to alter protein stability and function. Here...
2.
Zhao F, Ilbert M, Varadan R, Cremers C, Hoyos B, Acin-Perez R, et al.
Antioxid Redox Signal
. 2010 Nov;
14(5):757-66.
PMID: 21067413
Protein kinase C (PKC) is activated by lipid second messengers or redox action, raising the question whether these activation modes involve the same or alternate mechanisms. Here we show that...
3.
Dickinson B, Varadan R, Fushman D
Protein Sci
. 2007 Jan;
16(3):369-78.
PMID: 17242378
In solution, Lys48-linked di-ubiquitin exists in dynamic equilibrium between closed and open conformations. To understand the effect of interdomain motion in polyubiquitin chains on their ability to bind ligands, we...
4.
Eddins M, Varadan R, Fushman D, Pickart C, Wolberger C
J Mol Biol
. 2007 Jan;
367(1):204-11.
PMID: 17240395
Ubiquitin modification of proteins is used as a signal in many cellular processes. Lysine side-chains can be modified by a single ubiquitin or by a polyubiquitin chain, which is defined...
5.
Varadan R, Assfalg M, Fushman D
Methods Enzymol
. 2005 Dec;
399:177-92.
PMID: 16338356
Polyubiquitin (polyUb) chains function as signaling molecules that mediate a diverse set of cellular events. The outcome of polyubiquitination depends on the specific linkage between Ub moieties in the chain,...
6.
Raasi S, Varadan R, Fushman D, Pickart C
Nat Struct Mol Biol
. 2005 Jul;
12(8):708-14.
PMID: 16007098
The ubiquitin-associated (UBA) domain occurs frequently in proteins involved in ubiquitin-dependent signaling pathways. Although polyubiquitin chain binding is considered to be a defining feature of the UBA domain family, the...
7.
Varadan R, Assfalg M, Raasi S, Pickart C, Fushman D
Mol Cell
. 2005 Jun;
18(6):687-98.
PMID: 15949443
Although functional diversity in polyubiquitin chain signaling has been ascribed to the ability of differently linked chains to bind in a distinctive manner to effector proteins, structural models of such...
8.
Verma R, Peters N, DOnofrio M, Tochtrop G, Sakamoto K, Varadan R, et al.
Science
. 2004 Oct;
306(5693):117-20.
PMID: 15459393
To identify previously unknown small molecules that inhibit cell cycle machinery, we performed a chemical genetic screen in Xenopus extracts. One class of inhibitors, termed ubistatins, blocked cell cycle progression...
9.
Walker O, Varadan R, Fushman D
J Magn Reson
. 2004 May;
168(2):336-45.
PMID: 15140445
We present a computer program ROTDIF for efficient determination of a complete rotational diffusion tensor of a molecule from NMR relaxation data. The derivation of the rotational diffusion tensor in...
10.
Varadan R, Assfalg M, Haririnia A, Raasi S, Pickart C, Fushman D
J Biol Chem
. 2003 Dec;
279(8):7055-63.
PMID: 14645257
Diverse cellular events are regulated by post-translational modification of substrate proteins via covalent attachment of one or a chain of ubiquitin molecules. The outcome of (poly)ubiquitination depends upon the specific...