Michael Assfalg
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Explore the profile of Michael Assfalg including associated specialties, affiliations and a list of published articles.
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82
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1070
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Recent Articles
1.
Scintilla S, Rossetto D, Clemancey M, Rendon J, Ranieri A, Guella G, et al.
Chem Sci
. 2025 Feb;
16(11):4614-4624.
PMID: 39944125
Conditions that led to the synthesis of iron-sulfur clusters coordinated to tripeptides with a single thiolate ligand were investigated by UV-vis, NMR, EPR, and Mössbauer spectroscopies and by electrochemistry. Increasing...
2.
Trivellato D, Munari F, Assfalg M, Capaldi S, DOnofrio M
Chembiochem
. 2024 Sep;
25(22):e202400566.
PMID: 39291301
The microtubule-associated protein tau is an intrinsically disordered protein highly expressed in neuronal axons. In healthy neurons, tau regulates microtubule dynamics and neurite outgrowth. However, pathological conditions can trigger aberrant...
3.
Viola G, Trivellato D, Meulli L, Tira R, Lauriola A, Munari F, et al.
Bioorg Chem
. 2024 Jun;
150:107549.
PMID: 38896934
Protein semisynthesis approaches are key for gaining insights into the effects of post-translational modifications (PTMs) on the structure and function of modified proteins. Among PTMs, ubiquitination involves the conjugation of...
4.
Grifagni D, Lenci E, De Santis A, Orsetti A, Barracchia C, Tedesco F, et al.
ACS Med Chem Lett
. 2024 Feb;
15(2):250-257.
PMID: 38352832
We have applied a proteolysis targeting chimera (PROTAC) technology to obtain a peptidomimetic molecule able to trigger the degradation of SARS-CoV-2 3-chymotrypsin-like protease (3CL). The PROTAC molecule was designed by...
5.
Parolini F, Kachoie E, Leo G, Civiero L, Bubacco L, Arrigoni G, et al.
Angew Chem Int Ed Engl
. 2023 Oct;
62(50):e202310230.
PMID: 37878393
Post-translational modifications of Tau are emerging as key players in determining the onset and progression of different tauopathies such as Alzheimer's disease, and are recognized to mediate the structural diversity...
6.
Tira R, Viola G, Barracchia C, Parolini F, Munari F, Capaldi S, et al.
J Agric Food Chem
. 2023 Jul;
71(30):11429-11441.
PMID: 37466260
Espresso coffee is among the most consumed beverages in the world. Recent studies report a protective activity of the coffee beverage against neurodegenerative disorders such as Alzheimer's disease. Alzheimer's disease...
7.
Viola G, Floriani F, Barracchia C, Munari F, DOnofrio M, Assfalg M
Chemistry
. 2023 Jun;
29(46):e202301274.
PMID: 37293933
Liquid-liquid phase separation (LLPS) of biopolymers to form condensates is a widespread phenomenon in living cells. Agents that target or alter condensation can help uncover elusive physiological and pathological mechanisms....
8.
Trivellato D, Floriani F, Barracchia C, Munari F, DOnofrio M, Assfalg M
Bioorg Chem
. 2023 Jan;
132:106347.
PMID: 36630781
In Alzheimer's disease and related disorders called tauopathies, the microtubule-associated protein tau accumulates in the brain in the form of amyloid-like supramolecular filaments. As an intrinsically disordered protein, tau undergoes...
9.
Viola G, Barracchia C, Tira R, Parolini F, Leo G, Bellanda M, et al.
Nano Lett
. 2022 Nov;
22(22):8875-8882.
PMID: 36346924
Understanding the interactions between nanoparticles (NPs) and proteins is crucial for the successful application of NPs in biological contexts. Protein adsorption is dependent on particle size, and protein binding to...
10.
Barracchia C, Parolini F, Volpe A, Gori D, Munari F, Capaldi S, et al.
Bioconjug Chem
. 2022 Jun;
33(7):1261-1268.
PMID: 35686491
Intrinsically disordered proteins (IDPs) are increasingly found to be associated with irreversible neurodegenerative disorders. The protein tau is a prototypical IDP whose abnormal aggregation into insoluble filaments is a major...