Ranganathan Arunkumar
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Explore the profile of Ranganathan Arunkumar including associated specialties, affiliations and a list of published articles.
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16
Citations
204
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Recent Articles
1.
Yang Z, Gorusupudi A, Lydic T, Mondal A, Sato S, Yamazaki I, et al.
iScience
. 2023 Dec;
26(12):108411.
PMID: 38047069
Very-long-chain polyunsaturated fatty acids (VLCPUFAs; C24-38) constitute a unique class of PUFA that have important biological roles, but the lack of a suitable dietary source has limited research in this...
2.
Arunkumar R, Bernstein P
Adv Exp Med Biol
. 2023 Jul;
1415:15-20.
PMID: 37440008
Lutein (L), zeaxanthin (Z), and meso-zeaxanthin (MZ) are the three macular pigments (MP) carotenoids that uniquely accumulate in the macula lutea region of the human retina. L and Z are...
3.
Addo E, Allman S, Arunkumar R, Gorka J, Harrison D, Varner M, et al.
J Nutr
. 2023 May;
153(8):2205-2215.
PMID: 37247819
Background: Adding carotenoids, particularly lutein (L) and zeaxanthin (Z), to prenatal micronutrient formulations has been promoted to enhance infant visual and neural development and to maintain maternal health. Although these...
4.
Arunkumar R, Baskaran V
J Funct Biomater
. 2023 Apr;
14(4).
PMID: 37103287
Lutein, a photo- and thermo-labile macular pigment, prevents the retina from suffering ocular inflammation with its antioxidant and anti-inflammatory activity. However, its biological activity is poor due to poor solubility...
5.
Arunkumar R, Li B, Addo E, Hartnett M, Bernstein P
Invest Ophthalmol Vis Sci
. 2023 Apr;
64(4):9.
PMID: 37036416
Purpose: Premature infants at risk of retinopathy of prematurity (ROP) miss placental transfer of the carotenoids lutein (L) and zeaxanthin (Z) during the third trimester. We previously demonstrated that prenatal...
6.
Li B, George E, Vachali P, Chang F, Gorusupudi A, Arunkumar R, et al.
Exp Eye Res
. 2023 Mar;
229:109429.
PMID: 36863431
The macular carotenoids lutein and zeaxanthin are taken up from the bloodstream into the human retina through a selective process, for which the HDL cholesterol receptor scavenger receptor BI (SR-BI)...
7.
Li B, Gorusupudi A, Arunkumar R, Bernstein P
Methods Enzymol
. 2022 Aug;
674:185-213.
PMID: 36008007
The term "macular carotenoids" refers to the lutein, zeaxanthin, and meso-zeaxanthin that are highly concentrated at the center of the human retina. Intraretinal levels of these carotenoids are inversely associated...
8.
Li B, Vachali P, Chang F, Gorusupudi A, Arunkumar R, Shi L, et al.
Arch Biochem Biophys
. 2021 Dec;
716:109111.
PMID: 34942193
Supplementation with antioxidant carotenoids is a therapeutic strategy to protect against age-related macular degeneration (AMD); however, the transport mechanism of carotenoids from the liver to the retina is still not...
9.
Arunkumar R, Gorusupudi A, Li B, Blount J, Nwagbo U, Kim H, et al.
Exp Eye Res
. 2021 Jun;
209:108680.
PMID: 34161819
Accumulation of bisretinoids such as A2E and its isomer iso-A2E is thought to mediate blue light-induced oxidative damage associated with age-related macular degeneration (AMD) and autosomal recessive Stargardt disease (STGD1)....
10.
Gorusupudi A, Rallabandi R, Li B, Arunkumar R, Blount J, Rognon G, et al.
Proc Natl Acad Sci U S A
. 2021 Feb;
118(6).
PMID: 33526677
Rare, nondietary very-long-chain polyunsaturated fatty acids (VLC-PUFAs) are uniquely found in the retina and a few other vertebrate tissues. These special fatty acids play a clinically significant role in retinal...