Ran Ren
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Explore the profile of Ran Ren including associated specialties, affiliations and a list of published articles.
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Articles
59
Citations
627
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Recent Articles
1.
Rao D, Wang Y, Yang X, Chen Z, Wu F, Ren R, et al.
Eur J Med Chem
. 2025 Feb;
288:117410.
PMID: 39978110
Targeting histone lysine demethylase 4 (KDM4) has emerged as a promising approach for cancer therapy. Despite significant progress in developing KDM4 inhibitors, many of these compounds demonstrate poor selectivity or...
2.
Design, synthesis and biological evaluation of dual CDK9/PARP inhibitors for the treatment of cancer
Huang J, He Y, Chen S, Ren R, Zhang S, Zhang J, et al.
Eur J Med Chem
. 2025 Feb;
287:117367.
PMID: 39947055
Combination of CDK9 and PARP inhibitors has demonstrated synergistic anticancer activity in ovarian cancer and triple-negative breast cancer (TNBC). In this study, we report the design and discovery of a...
3.
Wang J, Chen Y, Xu Y, Zhang J, Yang S, Zhou Y, et al.
Theranostics
. 2024 Oct;
14(17):6798-6817.
PMID: 39479454
The introduction of combination therapy utilizing tyrosine kinase inhibitors (TKIs) and immune checkpoint inhibitors for advanced hepatocellular carcinoma (HCC) has significantly altered the management of affected patients. However, the absence...
4.
Ren R, Chen Y, Zhou Y, Shen L, Chen Y, Lei J, et al.
Genes Dis
. 2024 Sep;
11(6):101281.
PMID: 39281833
Dysregulated calcium (Ca) signaling pathways are associated with tumor cell death and drug resistance. In non-excitable cells, such as hepatocellular carcinoma (HCC) cells, the primary pathway for Ca influx is...
5.
Shen L, Wang C, Ren R, Liu X, Zhou D, Chen Y, et al.
Inflamm Res
. 2024 Jul;
73(9):1493-1510.
PMID: 38981913
Objective And Design: Compelling evidence indicates that dysregulated macrophages may play a key role in driving inflammation in inflammatory bowel disease (IBD). Fibroblast growth factor (FGF)-19, which is secreted by...
6.
Chen Y, Zhou Y, Ren R, Chen Y, Lei J, Li Y
J Immunother Cancer
. 2024 Jul;
12(7).
PMID: 38977328
Background: While anti-programmed cell death protein-1 (PD-1) monotherapy has shown effectiveness in treating lung cancer, its response rate is limited to approximately 20%. Recent research suggests that abnormal lipid metabolism...
7.
GPAT3 is a potential therapeutic target to overcome sorafenib resistance in hepatocellular carcinoma
Zhou Y, Zhao H, Ren R, Zhou M, Zhang J, Wu Z, et al.
Theranostics
. 2024 Jul;
14(9):3470-3485.
PMID: 38948063
Sorafenib is the standard treatment for advanced hepatocellular carcinoma (HCC), but acquired resistance during the treatment greatly limits its clinical efficiency. Lipid metabolic disorder plays an important role in hepatocarcinogenesis....
8.
Wang T, Zhao W, Ren R, Lan H, Zhou T, Hu J, et al.
J Colloid Interface Sci
. 2024 Jun;
674:19-28.
PMID: 38909591
Exploring robust electrode materials which could permit fast and reversible insertion/extraction of large K is a crucial challenge for potassium-ion batteries (PIBs). Smart interfacial design could facilitate electron/ion transport as...
9.
Liu D, Yuan J, Ren R, Gao W, Guo L, Ni J
Eur J Radiol
. 2024 Mar;
175:111435.
PMID: 38537606
Purpose: The Alberta Stroke Program Early Computed Tomography Score (ASPECTS) is a standardized semi-quantitative scoring system. It is widely used to assess the extent of acute ischemic stroke (AIS). We...
10.
Chen P, Liu Y, Yang J, Wang D, Ren R, Li Y, et al.
Eur Arch Otorhinolaryngol
. 2024 Feb;
281(8):4039-4047.
PMID: 38365989
Purpose: First-generation bone bridges (BBs) have demonstrated favorable safety and audiological benefits in patients with conductive hearing loss. However, studies on the effects of second-generation BBs are limited, especially among...