Ramachandran Balasubramanian
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Explore the profile of Ramachandran Balasubramanian including associated specialties, affiliations and a list of published articles.
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22
Citations
330
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Recent Articles
1.
Junker A, Renn C, Dobelmann C, Namasivayam V, Jain S, Losenkova K, et al.
J Med Chem
. 2019 Mar;
62(7):3677-3695.
PMID: 30895781
Cluster of differentiation 73 (CD73) converts adenosine 5'-monophosphate to immunosuppressive adenosine, and its inhibition was proposed as a new strategy for cancer treatment. We synthesized 5'- O-[(phosphonomethyl)phosphonic acid] derivatives of...
2.
Toti K, Jain S, Ciancetta A, Balasubramanian R, Chakraborty S, Surujdin R, et al.
Medchemcomm
. 2018 Feb;
8(10):1897-1908.
PMID: 29423136
Both agonists and antagonists of the UDP-activated P2Y receptor (P2YR) have been proposed for therapeutic use, in conditions such as cancer, inflammation, neurodegeneration and diabetes. Uracil nucleotides containing a South-bicyclo[3.1.0]hexane...
3.
Junker A, Balasubramanian R, Ciancetta A, Uliassi E, Kiselev E, Martiriggiano C, et al.
J Med Chem
. 2016 Jun;
59(13):6149-68.
PMID: 27331270
UDP and UDP-glucose activate the P2Y14 receptor (P2Y14R) to modulate processes related to inflammation, diabetes, and asthma. A computational pipeline suggested alternatives to naphthalene of a previously reported P2Y14R antagonist...
4.
Kiselev E, Balasubramanian R, Uliassi E, Brown K, Trujillo K, Katritch V, et al.
Bioorg Med Chem Lett
. 2015 Aug;
25(21):4733-4739.
PMID: 26303895
The P2Y14R is a G(i/o)-coupled receptor of the P2Y family of purinergic receptors that is activated by extracellular UDP and UDP-glucose (UDPG). In an earlier report we described a P2Y14R...
5.
Jayasekara P, Barrett M, Ball C, Brown K, Kozma E, Costanzi S, et al.
Medchemcomm
. 2015 Jul;
4:1156-1165.
PMID: 26161252
4-Alkyloxyimino derivatives of pyrimidine nucleotides display high potency as agonists of certain G protein-coupled P2Y receptors (P2YRs). In an effort to functionalize a P2YR agonist for fluorescent labeling, we probed...
6.
Goure E, Carboni M, Troussier A, Dubourdeaux P, Clemancey M, Gon N, et al.
Inorg Chem
. 2015 Jun;
54(13):6257-66.
PMID: 26091015
We have previously investigated cis/trans isomerization processes in phenoxido-bridged mixed-valent Fe(II)Fe(III) complexes that contain either one aniline or one anilide ligand. In this work, we compare the properties of similar...
7.
Jacobson K, Gao Z, Paoletta S, Kiselev E, Chakraborty S, Jayasekara P, et al.
Comput Struct Biotechnol J
. 2015 May;
13:286-98.
PMID: 25973142
We establish structure activity relationships of extracellular nucleosides and nucleotides at G protein-coupled receptors (GPCRs), e.g. adenosine receptors (ARs) and P2Y receptors (P2YRs), respectively. We synthesize selective agents for use...
8.
Balasubramanian R, Robaye B, Boeynaems J, Jacobson K
PLoS One
. 2014 Dec;
9(12):e116203.
PMID: 25549240
Glucose uptake by peripheral tissues such as skeletal muscles and adipocytes is important in the maintenance of glucose homeostasis. We previously demonstrated that P2Y6 receptor (P2Y6R) agonists protect pancreatic islet...
9.
Goure E, Carboni M, Dubourdeaux P, Clemancey M, Balasubramanian R, Lebrun C, et al.
Inorg Chem
. 2014 Sep;
53(19):10060-9.
PMID: 25254906
We have recently reported a deprotonation-induced valence inversion within a phenoxido-bridged mixed-valent diiron(II,III) complex. The initial aniline coordinated to the Fe(II) site reacts with triethylamine, and the resulting complex contains...
10.
Gao Z, Balasubramanian R, Kiselev E, Wei Q, Jacobson K
Biochem Pharmacol
. 2014 May;
90(3):297-306.
PMID: 24853985
G protein-coupled A(2B) adenosine receptor (AR) regulates numerous important physiological functions, but its activation by diverse A(2B)AR agonists is poorly profiled. We probed potential partial and/or biased agonism in cell...