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Ram H Nagaraj

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Articles 89
Citations 1327
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Recent Articles
1.
Panja S, Rankenberg J, Michel C, Cooksley G, Glomb M, Nagaraj R
J Biol Chem . 2025 Mar; :108377. PMID: 40049410
Advanced glycation end products (AGEs) are protein modifications resulting from the chemical reaction between lysine and arginine residues in proteins, and carbonyl compounds, including glyoxal (GO) and methylglyoxal (MGO). N-carboxymethyllysine...
2.
Johnson G, Krishnamoorthy R, Nagaraj R, Stankowska D
Biomolecules . 2025 Feb; 15(2). PMID: 40001522
This study evaluated the neuroprotective potential of peptain-1 conjugated to a cell-penetrating peptide (CPP-P1) in an ocular hypertension model of glaucoma. Brown Norway (BN) rats were subjected to intraocular pressure...
3.
Cooksley G, Nam M, Nahomi R, Rankenberg J, Smith A, Wormstone Y, et al.
Aging Cell . 2024 Oct; 23(10):e14249. PMID: 39384405
Posterior capsule opacification (PCO) is a common complication after cataract surgery. Residual lens epithelial cells (LECs) on the anterior lens capsule, after cataract surgery, migrate to the posterior lens capsule...
4.
Nam M, Dhillon A, Nahomi R, Carrillo N, Hougen C, Nagaraj R
Front Cell Neurosci . 2024 Aug; 18:1441924. PMID: 39149168
Introduction: Neurovascular degeneration results in vascular dysfunction, leakage, ischemia, and structural changes that can lead to significant visual impairment. We previously showed the protective effects of peptain-1, a 20 amino...
5.
Panja S, Nam M, Gaikwad H, Rankenberg J, Nagaraj R
Front Ophthalmol (Lausanne) . 2024 Jul; 3:1274825. PMID: 38983035
Presbyopia is the progressive loss of the ability of the lens to focus on nearby objects due to its increased stiffness. It occurs in the mid-40s and continues to worsen...
6.
Johnson G, Kodati B, Nahomi R, Pham J, Krishnamoorthy V, Phillips N, et al.
Cell Death Discov . 2024 Jun; 10(1):305. PMID: 38942762
This study assesses the neuroprotective potential of CPP-P1, a conjugate of an anti-apoptotic peptain-1 (P1) and a cell-penetrating peptide (CPP) in in vitro, in vivo, and ex vivo glaucoma models....
7.
Schwab S, Harris P, Michel C, McGinnis C, Nahomi R, Assiri M, et al.
Proteomics Clin Appl . 2024 Jun; 18(6):e202400018. PMID: 38923810
Purpose: Diabetic kidney disease (DKD) is a serious complication of diabetes mellitus and a leading cause of chronic kidney disease and end-stage renal disease. One potential mechanism underlying cellular dysfunction...
8.
Panja S, Nahomi R, Rankenberg J, Michel C, Nagaraj R
ACS Chem Biol . 2024 Jun; 19(7):1495-1505. PMID: 38904252
Lysine acetylation (AcK) is a prominent post-translational modification in eye lens crystallins. We have observed that AcK formation is preferred in some lysine residues over others in crystallins. In this...
9.
Portillo J, Pfaff A, Vos S, Weng M, Nagaraj R, Subauste C
Cells . 2024 Mar; 13(5. PMID: 38474393
CD40 induces pro-inflammatory responses in endothelial and Müller cells and is required for the development of diabetic retinopathy (DR). CD40 is upregulated in these cells in patients with DR. CD40...
10.
Panja S, Nahomi R, Rankenberg J, Michel C, Gaikwad H, Nam M, et al.
Aging Cell . 2023 Feb; 22(4):e13797. PMID: 36823285
Aging proteins in the lens become increasingly aggregated and insoluble, contributing to presbyopia. In this study, we investigated the ability of aggrelyte-2 (N,S-diacetyl-L-cysteine methyl ester) to reverse the water insolubility...