Ralph Riedl
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Explore the profile of Ralph Riedl including associated specialties, affiliations and a list of published articles.
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18
Citations
728
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Recent Articles
11.
Hassan A, Kirby C, Zhou W, Schuhmann T, Kityk R, Kipp D, et al.
Chem Biol
. 2014 Dec;
22(1):87-97.
PMID: 25544045
The highly conserved 70 kDa heat shock proteins (Hsp70) play an integral role in proteostasis such that dysregulation has been implicated in numerous diseases. Elucidating the precise role of Hsp70...
12.
Hoepfner D, Helliwell S, Sadlish H, Schuierer S, Filipuzzi I, Brachat S, et al.
Microbiol Res
. 2013 Dec;
169(2-3):107-20.
PMID: 24360837
Due to evolutionary conservation of biology, experimental knowledge captured from genetic studies in eukaryotic model organisms provides insight into human cellular pathways and ultimately physiology. Yeast chemogenomic profiling is a...
13.
Sadlish H, Galicia-Vazquez G, Paris C, Aust T, Bhullar B, Chang L, et al.
ACS Chem Biol
. 2013 Apr;
8(7):1519-27.
PMID: 23614532
Translation initiation is an emerging target in oncology and neurobiology indications. Naturally derived and synthetic rocaglamide scaffolds have been used to interrogate this pathway; however, there is uncertainty regarding their...
14.
Richie D, Thompson K, Studer C, Prindle V, Aust T, Riedl R, et al.
Antimicrob Agents Chemother
. 2013 Mar;
57(5):2272-80.
PMID: 23478965
High-throughput phenotypic screening against the yeast Saccharomyces cerevisiae revealed a series of triazolopyrimidine-sulfonamide compounds with broad-spectrum antifungal activity, no significant cytotoxicity, and low protein binding. To elucidate the target of...
15.
Nyfeler B, Hoepfner D, Palestrant D, Kirby C, Whitehead L, Yu R, et al.
PLoS One
. 2012 Sep;
7(9):e42657.
PMID: 22970117
Argyrins, produced by myxobacteria and actinomycetes, are cyclic octapeptides with antibacterial and antitumor activity. Here, we identify elongation factor G (EF-G) as the cellular target of argyrin B in bacteria,...
16.
Hoepfner D, McNamara C, Lim C, Studer C, Riedl R, Aust T, et al.
Cell Host Microbe
. 2012 Jun;
11(6):654-63.
PMID: 22704625
With renewed calls for malaria eradication, next-generation antimalarials need be active against drug-resistant parasites and efficacious against both liver- and blood-stage infections. We screened a natural product library to identify...
17.
van der Heijden M, Streitwolf-Engel R, Riedl R, Siegrist S, Neudecker A, Ineichen K, et al.
New Phytol
. 2006 Nov;
172(4):739-52.
PMID: 17096799
Previous studies have shown that arbuscular mycorrhizal fungi (AMF) can influence plant diversity and ecosystem productivity. However, little is known about the effects of AMF and different AMF taxa on...
18.
Renatus M, Parrado S, DArcy A, Eidhoff U, Gerhartz B, Hassiepen U, et al.
Structure
. 2006 Aug;
14(8):1293-302.
PMID: 16905103
Deubiquitinating proteases reverse protein ubiquitination and rescue their target proteins from destruction by the proteasome. USP2, a cysteine protease and a member of the ubiquitin specific protease family, is overexpressed...