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Ralph J Garippa

Explore the profile of Ralph J Garippa including associated specialties, affiliations and a list of published articles. Areas
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Articles 8
Citations 282
Followers 0
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Recent Articles
1.
Repin M, Garty G, Garippa R, Brenner D
Radiat Res . 2024 Mar; 201(6):567-571. PMID: 38514936
Micronuclei, detected through the cytokinesis-block micronucleus assay, are valuable indicators of ionizing radiation exposure, especially in short-term lymphocyte cultures. The peripheral human blood lymphocyte assay is recognized as a prime...
2.
Pelossof R, Fairchild L, Huang C, Widmer C, Sreedharan V, Sinha N, et al.
Nat Biotechnol . 2017 Mar; 35(4):350-353. PMID: 28263295
We present SplashRNA, a sequential classifier to predict potent microRNA-based short hairpin RNAs (shRNAs). Trained on published and novel data sets, SplashRNA outperforms previous algorithms and reliably predicts the most...
3.
Brea E, Oh C, Manchado E, Budhu S, Gejman R, Mo G, et al.
Cancer Immunol Res . 2016 Sep; 4(11):936-947. PMID: 27680026
The major histocompatibility complex I (MHC-1) presents antigenic peptides to tumor-specific CD8 T cells. The regulation of MHC-I by kinases is largely unstudied, even though many patients with cancer are...
4.
Miles L, Garippa R, Poirier J
FEBS J . 2016 Jun; 283(17):3170-80. PMID: 27250066
The recently described clustered regularly interspaced short palindromic repeats (CRISPR)/Cas9 technology has proven to be an exquisitely powerful and invaluable method of genetic manipulation and/or modification. As such, many researchers...
5.
Tschaharganeh D, Lowe S, Garippa R, Livshits G
FEBS J . 2016 May; 283(17):3194-203. PMID: 27149548
The recent discovery of the CRISPR/Cas system and repurposing of this technology to edit a variety of different genomes have revolutionized an array of scientific fields, from genetics and translational...
6.
Fennell M, Xiang Q, Hwang A, Chen C, Huang C, Chen C, et al.
J Biomol Screen . 2014 Aug; 19(10):1327-37. PMID: 25163683
For well over a decade, RNA interference (RNAi) has provided a powerful tool for investigators to query specific gene targets in an easily modulated loss-of-function setting, both in vitro and...
7.
Garippa R, Hoffman A, Gradl G, Kirsch A
Methods Enzymol . 2006 Nov; 414:99-120. PMID: 17110189
Ligand-activated G protein-coupled receptors (GPCRs) are known to regulate a myriad of homeostatic functions. Inappropriate signaling is associated with several pathophysiological states. GPCRs belong to a approximately 800 member superfamily...
8.
Hoffman A, Garippa R
Methods Mol Biol . 2006 Sep; 356:19-31. PMID: 16988392
It is early to fully reflect on the state of the art in high content screening (HCS), because it is still a relatively new approach in drug discovery. Although the...