Ralph B Perkerson
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Explore the profile of Ralph B Perkerson including associated specialties, affiliations and a list of published articles.
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12
Citations
797
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Recent Articles
1.
Ma X, Prokopenko D, Wang N, Aikawa T, Choi Y, Zhang C, et al.
Neurobiol Dis
. 2025 Jan;
206:106813.
PMID: 39880319
The adenosine triphosphate-binding cassette transporter A7 (ABCA7) gene is ranked as one of the top susceptibility loci for Alzheimer's disease (AD). While ABCA7 mediates lipid transport across cellular membranes, ABCA7...
2.
Oue H, Yamazaki Y, Qiao W, Yuanxin C, Ren Y, Kurti A, et al.
JCI Insight
. 2023 Apr;
8(7).
PMID: 37036005
Cerebrovasculature is critical in maintaining brain homeostasis; its dysregulation often leads to vascular cognitive impairment and dementia (VCID) during aging. VCID is the second most prevalent cause of dementia in...
3.
Ramos-Fresnedo A, Perez-Vega C, Domingo R, Lee S, Perkerson R, Zubair A, et al.
Epilepsia
. 2022 Apr;
63(7):1607-1618.
PMID: 35451066
Drug-resistant epilepsy (DRE) is characterized by recurrent seizures despite appropriate treatment with antiseizure medication (ASM). Due to their regenerative and immunomodulatory potential, therapies with biologics such as mesenchymal stem cells...
4.
Rademakers R, Nicholson A, Ren Y, Koga S, Nguyen H, Brooks M, et al.
Brain Pathol
. 2021 Mar;
31(3):e12945.
PMID: 33709463
TMEM106B has been recently implicated in multiple neurodegenerative diseases. Here, Rademakers et al. report a late-onset cerebellar Purkinje cell loss and progressive decline in motor function and gait deficits in...
5.
Zhou X, Nicholson A, Ren Y, Brooks M, Jiang P, Zuberi A, et al.
Brain
. 2020 Jun;
143(6):1905-1919.
PMID: 32504082
Genetic variants that define two distinct haplotypes at the TMEM106B locus have been implicated in multiple neurodegenerative diseases and in healthy brain ageing. In frontotemporal dementia (FTD), the high expressing...
6.
Josephs K, Murray M, Tosakulwong N, Weigand S, Serie A, Perkerson R, et al.
Acta Neuropathol
. 2019 Jan;
137(2):227-238.
PMID: 30604226
TDP-43 is present in a high proportion of aged brains that do not meet criteria for frontotemporal lobar degeneration (FTLD). We determined whether there are distinct TDP-43 types in non-FTLD...
7.
Nicholson A, Zhou X, Perkerson R, Parsons T, Chew J, Brooks M, et al.
Acta Neuropathol Commun
. 2018 Jun;
6(1):42.
PMID: 29855382
Loss-of-function mutations in progranulin (GRN) and a non-coding (GGGGCC) hexanucleotide repeat expansions in C9ORF72 are the two most common genetic causes of frontotemporal lobar degeneration with aggregates of TAR DNA...
8.
Mackenzie I, Nicholson A, Sarkar M, Messing J, Purice M, Pottier C, et al.
Neuron
. 2017 Aug;
95(4):808-816.e9.
PMID: 28817800
Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are age-related neurodegenerative disorders with shared genetic etiologies and overlapping clinical and pathological features. Here we studied a novel ALS/FTD family and...
9.
Nicholson A, Finch N, Almeida M, Perkerson R, van Blitterswijk M, Wojtas A, et al.
Nat Commun
. 2016 Jul;
7:11992.
PMID: 27356620
Progranulin (GRN) loss-of-function mutations leading to progranulin protein (PGRN) haploinsufficiency are prevalent genetic causes of frontotemporal dementia. Reports also indicated PGRN-mediated neuroprotection in models of Alzheimer's and Parkinson's disease; thus,...
10.
Prudencio M, Belzil V, Batra R, Ross C, Gendron T, Pregent L, et al.
Nat Neurosci
. 2015 Jul;
18(8):1175-82.
PMID: 26192745
Increasing evidence suggests that defective RNA processing contributes to the development of amyotrophic lateral sclerosis (ALS). This may be especially true for ALS caused by a repeat expansion in C9orf72...