Ralf M Leonhardt
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Explore the profile of Ralf M Leonhardt including associated specialties, affiliations and a list of published articles.
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23
Citations
424
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Recent Articles
1.
Mitchell S, Graham M, Liu X, Leonhardt R
Sci Rep
. 2021 Apr;
11(1):7730.
PMID: 33833328
The pigment cell-specific protein PMEL forms a functional amyloid matrix in melanosomes onto which the pigment melanin is deposited. The amyloid core consists of a short proteolytic fragment, which we...
2.
Graham M, Tzika A, Mitchell S, Liu X, Leonhardt R
Sci Rep
. 2019 Apr;
9(1):6101.
PMID: 30988362
PMEL is a pigment cell-specific protein that forms a functional amyloid matrix in melanosomes. The matrix consists of well-separated fibrillar sheets on which the pigment melanin is deposited. Using electron...
3.
Lahola-Chomiak A, Footz T, Nguyen-Phuoc K, Neil G, Fan B, Allen K, et al.
Hum Mol Genet
. 2018 Dec;
28(8):1298-1311.
PMID: 30561643
Pigmentary glaucoma (PG) is a common glaucoma subtype that results from release of pigment from the iris, called pigment dispersion syndrome (PDS), and its deposition throughout the anterior chamber of...
4.
Vigneron N, Ferrari V, Van den Eynde B, Cresswell P, Leonhardt R
J Immunol
. 2018 Aug;
201(7):1875-1888.
PMID: 30135181
Cancer immunotherapy has been flourishing in recent years with remarkable clinical success. But as more patients are treated, a shadow is emerging that has haunted other cancer therapies: tumors develop...
5.
Radomski N, Rebbig A, Leonhardt R, Knittler M
Int J Med Microbiol
. 2017 Nov;
308(1):185-196.
PMID: 29126745
Autophagy is an evolutionarily ancient and highly conserved eukaryotic mechanism that targets cytoplasmic material for degradation. Autophagic flux involves the formation of autophagosomes and their degradation by lysosomes. The process...
6.
Hee J, Mitchell S, Liu X, Leonhardt R
Sci Rep
. 2017 Mar;
7:44064.
PMID: 28272432
PMEL is a pigment cell protein that forms physiological amyloid in melanosomes. Many amyloids and/or their oligomeric precursors are toxic, causing or contributing to severe, incurable diseases including Alzheimer's and...
7.
Rufer E, Kagebein D, Leonhardt R, Knittler M
J Immunol
. 2015 Nov;
195(11):5482-94.
PMID: 26519531
The transporter associated with Ag processing (TAP) translocates proteasomally derived cytosolic peptides into the endoplasmic reticulum. TAP is a central component of the peptide-loading complex (PLC), to which tapasin (TPN)...
8.
Leonhardt R, Abrahimi P, Mitchell S, Cresswell P
J Immunol
. 2014 Feb;
192(5):2480-94.
PMID: 24501197
The TAP translocates peptide Ags into the lumen of the endoplasmic reticulum for loading onto MHC class I molecules. MHC class I acquires its peptide cargo in the peptide loading...
9.
Leonhardt R, Vigneron N, Hee J, Graham M, Cresswell P
Mol Biol Cell
. 2013 Feb;
24(7):964-81.
PMID: 23389629
PMEL (also called Pmel17 or gp100) is a melanocyte/melanoma-specific glycoprotein that plays a critical role in melanosome development by forming a fibrillar amyloid matrix in the organelle for melanin deposition....
10.
Panter M, Jain A, Leonhardt R, Ha T, Cresswell P
J Biol Chem
. 2012 Jul;
287(37):31172-84.
PMID: 22829594
Although the human peptide-loading complex (PLC) is required for optimal major histocompatibility complex class I (MHC I) antigen presentation, its composition is still incompletely understood. The ratio of the transporter...