Rajmohan Rajamuthiah
Overview
Explore the profile of Rajmohan Rajamuthiah including associated specialties, affiliations and a list of published articles.
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16
Citations
529
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Recent Articles
1.
Kim W, Zhu W, Hendricks G, Van Tyne D, Steele A, Keohane C, et al.
Nature
. 2018 Mar;
556(7699):103-107.
PMID: 29590091
A challenge in the treatment of Staphylococcus aureus infections is the high prevalence of methicillin-resistant S. aureus (MRSA) strains and the formation of non-growing, dormant 'persister' subpopulations that exhibit high...
2.
Tharmalingam N, Jayamani E, Rajamuthiah R, Castillo D, Fuchs B, Kelso M, et al.
Future Med Chem
. 2017 Aug;
9(12):1401-1411.
PMID: 28771026
Aim: Compound 1-(4-chlorophenyl)-4,4,4-trifluoro-3-hydroxy-2-buten-1-one (compound 1) was identified as a hit against methicillin-resistant Staphylococcus aureus (MRSA) strain MW2. Methods & Results: The MIC of compound 1 against MRSA was 4 μg/ml....
3.
Jayamani E, Tharmalingam N, Rajamuthiah R, Coleman J, Kim W, Okoli I, et al.
Antimicrob Agents Chemother
. 2017 Jun;
61(9).
PMID: 28652232
is a highly infectious Gram-negative intracellular pathogen that causes tularemia. Because of its potential as a bioterrorism agent, there is a need for new therapeutic agents. We therefore developed a...
4.
Kim W, Fricke N, Conery A, Fuchs B, Rajamuthiah R, Jayamani E, et al.
Future Med Chem
. 2016 Feb;
8(3):257-69.
PMID: 26910612
Background: NH125, a known WalK inhibitor kills MRSA persisters. However, its precise mode of action is still unknown. Methods & Results: The mode of action of NH125 was investigated by...
5.
Fuchs B, Rajamuthiah R, Souza A, Eatemadpour S, Rossoni R, Santos D, et al.
Future Med Chem
. 2016 Jan;
8(2):117-32.
PMID: 26808006
Background: We identified auranofin as an antimicrobial compound utilizing a high-throughput screen using a Caenorhabditis elegans-Staphylococcus aureus infection model. Results/methodology: Treatment of infected nematodes with auranofin resulted in a prolonged...
6.
Dolla N, Chen C, Larkins-Ford J, Rajamuthiah R, Jagadeesan S, Conery A, et al.
Aust J Chem
. 2016 Jan;
67:1471-1480.
PMID: 26806960
Berberine-INF55 hybrids are a promising class of antibacterials that combine berberine and the NorA multidrug resistance pump inhibitor INF55 (5-nitro-2-phenylindole) together in one molecule via a chemically stable linkage. Previous...
7.
Fuchs B, Li Y, Li D, Johnston T, Hendricks G, Li G, et al.
Mycopathologia
. 2015 Nov;
181(1-2):27.
PMID: 26525974
No abstract available.
8.
Rajamuthiah R, Jayamani E, Majed H, Conery A, Kim W, Kwon B, et al.
Bioorg Med Chem Lett
. 2015 Oct;
25(22):5203-7.
PMID: 26459212
The emergence of multidrug-resistant bacterial strains has heightened the need for new antimicrobial agents based on novel chemical scaffolds that are able to circumvent current modes of resistance. We recently...
9.
Fuchs B, Li Y, Li D, Johnston T, Hendricks G, Li G, et al.
Mycopathologia
. 2015 Sep;
181(1-2):17-25.
PMID: 26384671
The echinocandin family of drugs is well characterized for antifungal function that inhibits β-D-glucan synthesis. The aim of this work was to study whether micafungin, a member of the echinocandin...
10.
Rajamuthiah R, Jayamani E, Conery A, Fuchs B, Kim W, Johnston T, et al.
PLoS One
. 2015 Jun;
10(6):e0128576.
PMID: 26062137
The red flour beetle Tribolium castaneum is a common insect pest and has been established as a model beetle to study insect development and immunity. This study demonstrates that defensin...