Rajiv Kumar Jha
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Explore the profile of Rajiv Kumar Jha including associated specialties, affiliations and a list of published articles.
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Articles
37
Citations
408
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Recent Articles
11.
Rani P, Kalladi S, Bansia H, Rao S, Jha R, Jain P, et al.
J Mol Biol
. 2020 Aug;
432(20):5614-5631.
PMID: 32818489
Topoisomerases maintain topological homeostasis of bacterial chromosomes by catalysing changes in DNA linking number. The resolution of RNA entanglements occurring in the cell would also require catalytic action of topoisomerases....
12.
Franch O, Gutierrez-Corbo C, Dominguez-Asenjo B, Boesen T, Jensen P, Nejsum L, et al.
Nucleic Acids Res
. 2020 May;
48(11):6081-6091.
PMID: 32402089
Herein, we characterize the cellular uptake of a DNA structure generated by rolling circle DNA amplification. The structure, termed nanoflower, was fluorescently labeled by incorporation of ATTO488-dUTP allowing the intracellular...
13.
Jha R, Udupa S, Rai A, Rani P, Singh P, Govind S, et al.
Sci Rep
. 2020 Apr;
10(1):5802.
PMID: 32242064
Gre, one of the conserved transcription factors in bacteria, modulates RNA polymerase (RNAP) activity to ensure processivity and fidelity of RNA synthesis. Gre factors regulate transcription by inducing the intrinsic-endonucleolytic...
14.
Li K, Zhan W, Jia M, Zhao Y, Liu Y, Jha R, et al.
Int J Med Sci
. 2020 Mar;
17(3):390-402.
PMID: 32132874
: Combination chemotherapy plays an important role in the clinical therapy of non-small cell lung cancer (NSCLC). However, the pharmacokinetic differences between drugs are an insurmountable barrier in traditional treatment....
15.
Li K, Zhan W, Chen Y, Jha R, Chen X
Front Pharmacol
. 2020 Jan;
10:1436.
PMID: 31920642
Combination chemotherapy has been proven to be an efficient strategy for the treatment of prostate cancer (PCA). However, the pharmacokinetic distinction between the relevant drugs is an insurmountable barrier to...
16.
Thapa P, Shahi S, Jha R, Shrestha D
World J Oncol
. 2019 May;
10(2):118-122.
PMID: 31068992
Background: Tumors related to the acoustic nerves represent 90% of cerebellopontine angle diseases and have been in the picture for at least 200 years. Famous as acoustic neuromas and vestibular...
17.
Datta C, Jha R, Ganguly S, Nagaraja V
J Mol Biol
. 2019 Mar;
431(8):1576-1591.
PMID: 30872139
Comparison of Mycobacterium tuberculosis with Escherichia coli reveals a reduction in the diversity of DNA-managing proteins, such as DNA topoisomerases, although genome sizes are similar for the two species. The...
18.
Datta C, Jha R, Ahmed W, Ganguly S, Ghosh S, Nagaraja V
Mol Microbiol
. 2019 Jan;
111(4):981-994.
PMID: 30633392
Nucleoid-associated proteins (NAPs) in bacteria contribute to key activities such as DNA compaction, chromosome organization and regulation of gene expression. HU and Lsr2 are two principal NAPs in Mycobacterium tuberculosis...
19.
Jha R, Tare P, Nagaraja V
Biochem Biophys Res Commun
. 2018 May;
501(4):877-884.
PMID: 29775608
DNA gyrase introduces negative supercoils into DNA to maintain topological homeostasis. The genes encoding gyrase, gyrB and gyrA, form a dicistronic operon in Mycobacterium tuberculosis (Mtb) and other actinobacteria. Earlier...
20.
Mishra S, Shukla P, Bhaskar A, Anand K, Baloni P, Jha R, et al.
Elife
. 2017 May;
6.
PMID: 28548640
() expresses a broad-spectrum β-lactamase (BlaC) that mediates resistance to one of the highly effective antibacterials, β-lactams. Nonetheless, β-lactams showed mycobactericidal activity in combination with β-lactamase inhibitor, clavulanate (Clav). However,...