Rajindra P Aryal
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Explore the profile of Rajindra P Aryal including associated specialties, affiliations and a list of published articles.
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Recent Articles
1.
Aryal R, Ramanujan A, Bucci C, Neckelmann C, Heimburg-Molinaro J, Cummings S, et al.
J Inherit Metab Dis
. 2025 Feb;
48(2):e70006.
PMID: 39949072
Cosmc, encoded by the X-linked C1GALT1C1, is a molecular chaperone in the endoplasmic reticulum and a master regulator of O-glycosylation of mammalian glycoproteins. Recently, we described a germline mutation in...
2.
Broekhuis J, Lu D, Aryal R, Matsumoto Y, Pepi L, Chaves N, et al.
Biomolecules
. 2025 Jan;
14(12.
PMID: 39766189
Aberrant protein glycosylation is a hallmark alteration of cancer and is highly associated with cancer progression. Papillary thyroid cancer (PTC) is the most common type of thyroid cancer, but the...
3.
Aryal R, Noel M, Zeng J, Matsumoto Y, Sinard R, Waki H, et al.
Glycobiology
. 2024 Aug;
34(10).
PMID: 39216105
Hepatocytes synthesize a vast number of glycoproteins found in their membranes and secretions, many of which contain O-glycans linked to Ser/Thr residues. As the functions and distribution of O-glycans on...
4.
Suttapitugsakul S, Matsumoto Y, Aryal R, Cummings R
Anal Chem
. 2023 Aug;
95(36):13423-13430.
PMID: 37624755
Altered protein glycosylation is typically associated with cognitive defects and other phenotypes, but there is a lack of knowledge about the brain glycoproteome. Here, we used the newly available -glycoprotease...
5.
Erger F, Aryal R, Reusch B, Matsumoto Y, Meyer R, Zeng J, et al.
Proc Natl Acad Sci U S A
. 2023 May;
120(22):e2211087120.
PMID: 37216524
Mutations in genes encoding molecular chaperones can lead to chaperonopathies, but none have so far been identified causing congenital disorders of glycosylation. Here we identified two maternal half-brothers with a...
6.
Matsumoto Y, Aryal R, Heimburg-Molinaro J, Park S, Wever W, Lehoux S, et al.
Sci Adv
. 2022 Oct;
8(43):eabm8783.
PMID: 36306365
The underlying pathology of immunoglobulin A (IgA) nephropathy (IgAN), the most common glomerulonephritis worldwide, is driven by the deposition of immune complexes containing galactose-deficient IgA1 [Tn(+)IgA1] in the glomerular mesangium....
7.
Zeng J, Aryal R, Stavenhagen K, Luo C, Liu R, Wang X, et al.
Sci Adv
. 2021 Oct;
7(41):eabg9118.
PMID: 34613773
Factors regulating the induction and development of B cell–mediated autoimmunity are not well understood. Here, we report that targeted deletion in murine B cells of X-linked , encoding the chaperone...
8.
Zeng J, Eljalby M, Aryal R, Lehoux S, Stavenhagen K, Kudelka M, et al.
Nat Commun
. 2020 Aug;
11(1):3990.
PMID: 32778659
The molecular mechanisms regulating lymphocyte homing into lymph nodes are only partly understood. Here, we report that B cell-specific deletion of the X-linked gene, Cosmc, and the consequent decrease of...
9.
McKitrick T, Eris D, Mondal N, Aryal R, McCurley N, Heimburg-Molinaro J, et al.
Biochemistry
. 2020 Feb;
59(34):3111-3122.
PMID: 32052624
The repertoire of glycans expressed by individual cells and tissues is enormous, and various estimates indicate that thousands of different glycans and "glycan determinants" are critical for functional recognition by...
10.
Aryal R, Kwak P, Tamayo A, Gebert M, Chiu P, Walz T, et al.
Mol Cell
. 2017 Sep;
67(5):770-782.e6.
PMID: 28886335
The mammalian circadian clock is built on a feedback loop in which PER and CRY proteins repress their own transcription. We found that in mouse liver nuclei all three PERs,...