Rajendran Sanalkumar
Overview
Explore the profile of Rajendran Sanalkumar including associated specialties, affiliations and a list of published articles.
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Articles
26
Citations
714
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Recent Articles
1.
Parvathy S, Basu B, Surya S, Jose R, Meera V, Riya P, et al.
iScience
. 2024 Dec;
27(12):111260.
PMID: 39628587
, a master regulator of the fate specification of excitatory neurons, is primarily known to function in post-mitotic cells. Although we have previously identified TLX3 expression in the proliferating granule...
2.
Boulay G, Broye L, Dong R, Iyer S, Sanalkumar R, Xing Y, et al.
Nat Commun
. 2024 Aug;
15(1):7460.
PMID: 39198430
EWS fusion oncoproteins underlie several human malignancies including Desmoplastic Small Round Cell Tumor (DSRCT), an aggressive cancer driven by EWS-WT1 fusion proteins. Here we combine chromatin occupancy and 3D profiles...
3.
Sundaramoorthy S, Colombo D, Sanalkumar R, Broye L, Balmas Bourloud K, Boulay G, et al.
JCI Insight
. 2024 Aug;
9(14).
PMID: 39133652
The development of targeted therapies offers new hope for patients affected by incurable cancer. However, multiple challenges persist, notably in controlling tumor cell plasticity in patients with refractory and metastatic...
4.
Bakaric A, Cironi L, Praz V, Sanalkumar R, Broye L, Favre-Bulle K, et al.
Cancers (Basel)
. 2024 Jan;
16(2).
PMID: 38275898
CIC-DUX4-rearranged sarcoma (CDS) is a rare and aggressive soft tissue tumor that occurs most frequently in young adults. The key oncogenic driver of this disease is the expression of the...
5.
Sanalkumar R, Dong R, Lee L, Xing Y, Iyer S, Letovanec I, et al.
Sci Adv
. 2023 Mar;
9(13):eabo3789.
PMID: 37000878
Cell fate transitions observed in embryonic development involve changes in three-dimensional genomic organization that provide proper lineage specification. Whether similar events occur within tumor cells and contribute to cancer evolution...
6.
Katsumura K, Ong I, DeVilbiss A, Sanalkumar R, Bresnick E
Cell Rep
. 2016 Aug;
16(9):2428-41.
PMID: 27545880
The master regulatory transcription factor GATA-2 triggers hematopoietic stem and progenitor cell generation. GATA2 haploinsufficiency is implicated in myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML), and GATA2 overexpression portends...
7.
Divya T, Lalitha S, Parvathy S, Subashini C, Sanalkumar R, Dhanesh S, et al.
Sci Rep
. 2016 Jul;
6:30337.
PMID: 27452274
Homeobox gene Tlx3 is known to promote glutamatergic differentiation and is expressed in post-mitotic neurons of CNS. Contrary to this here, we discovered that Tlx3 is expressed in the proliferating...
8.
Liu P, Sanalkumar R, Bresnick E, Keles S, Dewey C
Genome Res
. 2016 Jul;
26(8):1124-33.
PMID: 27405803
RNA-seq is currently the technology of choice for global measurement of transcript abundances in cells. Despite its successes, isoform-level quantification remains difficult because short RNA-seq reads are often compatible with...
9.
Johnson K, Kong G, Gao X, Chang Y, Hewitt K, Sanalkumar R, et al.
Sci Adv
. 2015 Nov;
1(8):e1500503.
PMID: 26601269
Cis-element encyclopedias provide information on phenotypic diversity and disease mechanisms. Although cis-element polymorphisms and mutations are instructive, deciphering function remains challenging. Mutation of an intronic GATA motif (+9.5) in GATA2,...
10.
Hewitt K, Kim D, Devadas P, Prathibha R, Zuo C, Sanalkumar R, et al.
Mol Cell
. 2015 Jun;
59(1):62-74.
PMID: 26073540
Thousands of cis-elements in genomes are predicted to have vital functions. Although conservation, activity in surrogate assays, polymorphisms, and disease mutations provide functional clues, deletion from endogenous loci constitutes the...