Rajendra Upadhya
Overview
Explore the profile of Rajendra Upadhya including associated specialties, affiliations and a list of published articles.
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Articles
29
Citations
669
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0
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Recent Articles
1.
Immunological correlates of protection mediated by a whole organism, , vaccine deficient in chitosan
Specht C, Wang R, Oliveira L, Hester M, Gomez C, Mou Z, et al.
mBio
. 2024 Jul;
15(8):e0174624.
PMID: 38980038
Importance: The fungus is responsible for >100,000 deaths annually, mostly in persons with impaired CD4 T-cell function such as AIDS. There are no approved human vaccines. We previously created a...
2.
Specht C, Wang R, Oliveira L, Hester M, Gomez C, Mou Z, et al.
bioRxiv
. 2024 Jun;
PMID: 38915489
Importance: The fungus is responsible for >100,000 deaths annually, mostly in persons with impaired CD4 T cell function such as AIDS. There are no approved human vaccines. We previously created...
3.
Specht C, Lam W, Hester M, Lourenco D, Levitz S, Lodge J, et al.
Methods Mol Biol
. 2024 May;
2775:393-410.
PMID: 38758333
Creating a safe and effective vaccine against infection by the fungal pathogen Cryptococcus neoformans is an appealing option that complements the discovery of new small molecule antifungals. Recent animal studies...
4.
Maybruck B, Upadhya R, Lam W, Specht C, Lodge J
Methods Mol Biol
. 2024 May;
2775:329-347.
PMID: 38758327
The cell wall of the fungal pathogens Cryptococcus neoformans and C. gattii is critical for cell wall integrity and signaling external threats to the cell, allowing it to adapt and...
5.
Upadhya R, Probst C, Alspaugh J, Lodge J
Methods Mol Biol
. 2024 May;
2775:277-303.
PMID: 38758325
Cryptococcus neoformans is an opportunistic human fungal pathogen capable of surviving in a wide range of environments and hosts. It has been developed as a model organism to study fungal...
6.
Upadhya R, Lam W, Hole C, Vasselli J, Lodge J
Front Fungal Biol
. 2023 Aug;
4.
PMID: 37538303
Introduction: is a basidiomycete fungus that can cause meningoencephalitis, especially in immunocompromised patients. Cryptococcus grows in many different media, although little attention has been paid to the role of growth...
7.
Moreira-Walsh B, Ragsdale A, Lam W, Upadhya R, Xu E, Lodge J, et al.
mSphere
. 2022 Jun;
7(4):e0013422.
PMID: 35758672
The fungal pathogen Cryptococcus neoformans causes up to 278 000 infections each year globally, resulting in up to 180,000 deaths annually, mostly impacting immunocompromised people. Therapeutic options for C. neoformans...
8.
Upadhya R, Lam W, Hole C, Parchment D, Lee C, Specht C, et al.
Cell Surf
. 2021 Oct;
7:100066.
PMID: 34712865
Chitosan, a deacetylated form of chitin, is required for the virulence of . There are three chitin deacetylase genes (CDA) that are essential for chitosan production, and deletion of all...
9.
Hole C, Lam W, Upadhya R, Lodge J
mBio
. 2020 Feb;
11(1).
PMID: 32071275
infections are significant causes of morbidity and mortality among AIDS patients and the third most common invasive fungal infection in organ transplant recipients. One of the main interfaces between the...
10.
Lam W, Upadhya R, Specht C, Ragsdale A, Hole C, Levitz S, et al.
mSphere
. 2019 Oct;
4(5).
PMID: 31597720
R265 is a hypervirulent fungal strain responsible for the recent outbreak of cryptococcosis in Vancouver Island of British Columbia in Canada. It differs significantly from in its natural environment, its...