Rajendra Upadhya
Overview
Explore the profile of Rajendra Upadhya including associated specialties, affiliations and a list of published articles.
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29
Citations
669
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Recent Articles
11.
El Bissati K, Redel H, Ting L, Lykins J, McPhillie M, Upadhya R, et al.
Front Cell Infect Microbiol
. 2019 Mar;
9:9.
PMID: 30838177
Twenty-two compounds belonging to several classes of polyamine analogs have been examined for their ability to inhibit the growth of the human malaria parasite and . Four lead compounds from...
12.
Upadhya R, Baker L, Lam W, Specht C, Donlin M, Lodge J
mBio
. 2018 Nov;
9(6).
PMID: 30459196
Chitin is an essential component of the cell wall of conferring structural rigidity and integrity under diverse environmental conditions. Chitin deacetylase genes encode the enyzmes (chitin deacetylases [Cdas]) that deacetylate...
13.
Upadhya R, Lam W, Maybruck B, Donlin M, Chang A, Kayode S, et al.
Fungal Genet Biol
. 2017 Sep;
108:13-25.
PMID: 28870457
C. neoformans is an encapsulated fungal pathogen with defined asexual and sexual life cycles. Due to the availability of genetic and molecular tools for its manipulation, it has become a...
14.
Homer C, Summers D, Goranov A, Clarke S, Wiesner D, Diedrich J, et al.
Cell Host Microbe
. 2016 May;
19(6):849-64.
PMID: 27212659
Quorum sensing (QS) is a bacterial communication mechanism in which secreted signaling molecules impact population function and gene expression. QS-like phenomena have been reported in eukaryotes with largely unknown contributing...
15.
Upadhya R, Lam W, Maybruck B, Specht C, Levitz S, Lodge J
mBio
. 2016 May;
7(3).
PMID: 27165801
Unlabelled: Cryptococcus neoformans is a major opportunistic fungal pathogen that causes fatal meningoencephalitis in immunocompromised individuals and is responsible for a large proportion of AIDS-related deaths. The fungal cell wall...
16.
El Bissati K, Suvorova E, Xiao H, Lucas O, Upadhya R, Ma Y, et al.
mBio
. 2016 Feb;
7(1):e02094-15.
PMID: 26838719
Unlabelled: The arginine methyltransferase family (PRMT) has been implicated in a variety of cellular processes, including signal transduction, epigenetic regulation, and DNA repair pathways. PRMT1 is thought to be responsible...
17.
Donlin M, Upadhya R, Gerik K, Lam W, VanArendonk L, Specht C, et al.
mBio
. 2014 Aug;
5(4).
PMID: 25118241
Unlabelled: Cryptococcus neoformans is a fungal pathogen of immunocompromised people that causes fatal meningitis. The fungal cell wall is essential to viability and pathogenesis of C. neoformans, and biosynthesis and...
18.
Upadhya R, Donlin M, Lodge J
mBio
. 2014 Apr;
5(2):e01097.
PMID: 24757217
Meningitis is a frequent manifestation of infection due to Cryptococcus neoformans and a major cause of increased morbidity in patients with AIDS. Numerous in vitro gene expression and genetic studies...
19.
Upadhya R, Kim H, Jung K, Park G, Lam W, Lodge J, et al.
Mol Microbiol
. 2013 Sep;
90(3):630-648.
PMID: 23998805
Mechanisms of oxidative stress resistance are crucial virulence factors for survival and proliferation of fungal pathogens within the human host. In this study we have identified and functionally characterized the...
20.
Upadhya R, Campbell L, Donlin M, Aurora R, Lodge J
PLoS One
. 2013 Feb;
8(1):e55110.
PMID: 23383070
The ability of the opportunistic fungal pathogen Cryptococcus neoformans to resist oxidative stress is one of its most important virulence related traits. To cope with the deleterious effect of cellular...