Rajat Singhania
Overview
Explore the profile of Rajat Singhania including associated specialties, affiliations and a list of published articles.
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Articles
11
Citations
1462
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0
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Recent Articles
1.
Singhania R, Tyson J
Biology (Basel)
. 2023 Jun;
12(6).
PMID: 37372126
Large-scale protein regulatory networks, such as signal transduction systems, contain small-scale modules ('motifs') that carry out specific dynamical functions. Systematic characterization of the properties of small network motifs is therefore...
2.
Loo Yau H, Bell E, Ettayebi I, Campos de Almeida F, Boukhaled G, Shen S, et al.
Mol Cell
. 2021 Feb;
81(7):1469-1483.e8.
PMID: 33609448
We demonstrate that DNA hypomethylating agent (HMA) treatment can directly modulate the anti-tumor response and effector function of CD8 T cells. In vivo HMA treatment promotes CD8 T cell tumor...
3.
Abraham K, Khosraviani N, Chan J, Gorthi A, Samman A, Zhao D, et al.
Nature
. 2020 Jul;
585(7824):298-302.
PMID: 32669707
Proteins are manufactured by ribosomes-macromolecular complexes of protein and RNA molecules that are assembled within major nuclear compartments called nucleoli. Existing models suggest that RNA polymerases I and III (Pol...
4.
Shen S, Singhania R, Fehringer G, Chakravarthy A, Roehrl M, Chadwick D, et al.
Nature
. 2018 Nov;
563(7732):579-583.
PMID: 30429608
The use of liquid biopsies for cancer detection and management is rapidly gaining prominence. Current methods for the detection of circulating tumour DNA involve sequencing somatic mutations using cell-free DNA,...
5.
Casey A, Sinha A, Singhania R, Livingstone J, Waterhouse P, Tharmapalan P, et al.
J Cell Biol
. 2018 Jun;
217(8):2951-2974.
PMID: 29921600
The mammary epithelium depends on specific lineages and their stem and progenitor function to accommodate hormone-triggered physiological demands in the adult female. Perturbations of these lineages underpin breast cancer risk,...
6.
Sanchez M, Kolar S, Muller S, Reyes C, Wolf A, Ogawa C, et al.
Cell Host Microbe
. 2017 Sep;
22(4):543-551.e4.
PMID: 28943328
Humans do not usually develop effective immunity to Staphylococcus aureus reinfection. Using a murine model that mimics human infection, we show that lack of protective immunity to S. aureus systemic...
7.
Planello A, Singhania R, Kron K, Bailey S, Roulois D, Lupien M, et al.
Oncotarget
. 2016 Feb;
7(13):15772-86.
PMID: 26908456
Chronic periodontitis (CP) is a chronic inflammatory disease independently associated with higher incidence of oral cavity squamous cell carcinoma (OSCC). However, the molecular mechanism responsible for this increased incidence is...
8.
Roulois D, Loo Yau H, Singhania R, Wang Y, Danesh A, Shen S, et al.
Cell
. 2015 Aug;
162(5):961-73.
PMID: 26317465
DNA-demethylating agents have shown clinical anti-tumor efficacy via an unknown mechanism of action. Using a combination of experimental and bioinformatics analyses in colorectal cancer cells, we demonstrate that low-dose 5-AZA-CdR...
9.
Strong E, Butcher D, Singhania R, Mervis C, Morris C, de Carvalho D, et al.
Am J Hum Genet
. 2015 Jul;
97(2):216-27.
PMID: 26166478
Epigenetic dysfunction has been implicated in a growing list of disorders that include cancer, neurodevelopmental disorders, and neurodegeneration. Williams syndrome (WS) and 7q11.23 duplication syndrome (Dup7) are rare neurodevelopmental disorders...
10.
Planello A, Ji J, Sharma V, Singhania R, Mbabaali F, Muller F, et al.
Cell Regen
. 2014 Nov;
3(1):4.
PMID: 25408883
The conversion of somatic cells into pluripotent stem cells via overexpression of reprogramming factors involves epigenetic remodeling. DNA methylation at a significant proportion of CpG sites in induced pluripotent stem...