Daniel D De Carvalho
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Explore the profile of Daniel D De Carvalho including associated specialties, affiliations and a list of published articles.
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88
Citations
6099
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Recent Articles
1.
Ishak C, Marhon S, Tchrakian N, Hodgson A, Loo Yau H, Gonzaga I, et al.
Cancer Discov
. 2025 Jan;
PMID: 39776167
Epigenetic therapies facilitate transcription of immunogenic repetitive elements that cull cancer cells through 'viral mimicry' responses. Paradoxically, cancer-initiating events also facilitate transcription of repetitive elements. Contributions of repetitive element transcription...
2.
Chen R, He A, De Carvalho D
Mol Oncol
. 2024 Nov;
19(2):271-274.
PMID: 39592415
"Viral mimicry" refers to the induction of an innate immune response and interferon signaling by endogenous stimuli such as double-stranded RNA (dsRNA). This response has been shown to have strong...
3.
Sun S, You E, Hong J, Hoyos D, Del Priore I, Tsanov K, et al.
Immunity
. 2024 Nov;
57(12):2879-2894.e11.
PMID: 39577413
To thrive, cancer cells must navigate acute inflammatory signaling accompanying oncogenic transformation, such as via overexpression of repeat elements. We examined the relationship between immunostimulatory repeat expression, tumor evolution, and...
4.
Feng S, Marhon S, Sokolowski D, DCosta A, Soares F, Mehdipour P, et al.
Nat Commun
. 2024 Oct;
15(1):9321.
PMID: 39472584
Inactivating mutations in SMARCB1 confer an oncogenic dependency on EZH2 in atypical teratoid rhabdoid tumors (ATRTs), but the underlying mechanism has not been fully elucidated. We found that the sensitivity...
5.
Su P, Liu Y, Chen T, Xue Y, Zeng Y, Zhu G, et al.
Nat Genet
. 2024 Sep;
56(9):1890-1902.
PMID: 39227744
Functional genomic screens in two-dimensional cell culture models are limited in identifying therapeutic targets that influence the tumor microenvironment. By comparing targeted CRISPR-Cas9 screens in a two-dimensional culture with xenografts...
6.
Nassiri F, Ajisebutu A, Patil V, Mamatjan Y, Liu J, Wang J, et al.
Acta Neuropathol
. 2024 Apr;
147(1):68.
PMID: 38583102
Mutations in the pivotal metabolic isocitrate dehydrogenase (IDH) enzymes are recognized to drive the molecular footprint of diffuse gliomas, and patients with IDH mutant gliomas have overall favorable outcomes compared...
7.
Hosseini A, Lindholm H, Chen R, Mehdipour P, Marhon S, Ishak C, et al.
Cell Rep
. 2024 Jan;
43(2):113684.
PMID: 38261511
Viral mimicry describes the immune response induced by endogenous stimuli such as double-stranded RNA (dsRNA) from endogenous retroelements. Activation of viral mimicry has the potential to kill cancer cells or...
8.
Viner C, Ishak C, Johnson J, Walker N, Shi H, Sjoberg-Herrera M, et al.
Genome Biol
. 2024 Jan;
25(1):11.
PMID: 38191487
Background: Transcription factors bind DNA in specific sequence contexts. In addition to distinguishing one nucleobase from another, some transcription factors can distinguish between unmodified and modified bases. Current models of...
9.
Attie de Castro F, Mehdipour P, Chakravarthy A, Ettayebi I, Loo Yau H, Medina T, et al.
Br J Haematol
. 2023 Sep;
204(1):206-220.
PMID: 37726227
Progression to aggressive secondary acute myeloid leukaemia (sAML) poses a significant challenge in the management of myeloproliferative neoplasms (MPNs). Since the physiopathology of MPN is closely linked to the activation...
10.
Medina T, Murison A, Smith M, Kinker G, Chakravarthy A, Vitiello G, et al.
Front Immunol
. 2023 Aug;
14:1161901.
PMID: 37600767
Introduction: The imbalance between Th17 and regulatory T cells in inflammatory bowel diseases (IBD) promotes intestinal epithelial cell damage. In this scenario, T helper cell lineage commitment is accompanied by...