Rajani Kanta Mahapatra
Overview
Explore the profile of Rajani Kanta Mahapatra including associated specialties, affiliations and a list of published articles.
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Articles
38
Citations
164
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Recent Articles
11.
Arega A, Dhal A, Nayak S, Mahapatra R
J Mol Model
. 2022 May;
28(6):171.
PMID: 35624324
Tuberculosis caused by Mycobacterium tuberculosis (Mtb) is responsible for the highest global health problem, with the deaths of millions of people. With prevalence of multiple drug resistance (MDR) strains and...
12.
Panda C, Mahapatra R
Cell Mol Neurobiol
. 2022 Jan;
43(1):115-137.
PMID: 35066716
The innate immune system, as the first line of cellular defense, triggers a protective response called inflammation when encountered with invading pathogens. Inflammasome is a multi-protein cytosolic signaling complex that...
13.
Mengistu Asmare M, Nitin N, Yun S, Mahapatra R
J Mol Graph Model
. 2021 Dec;
111:108108.
PMID: 34911011
Cryptosporidium parvum (Cp) causes a gastro-intestinal disease called Cryptosporidiosis. C. parvum Inosine 5' monophosphate dehydrogenase (CpIMPDH) is responsible for the production of guanine nucleotides. In the present study, 37 known...
14.
Arega A, Mahapatra R
Chem Biol Drug Des
. 2021 Apr;
98(1):30-48.
PMID: 33838076
With the emergence of multidrug-resistant bacteria, insufficiency of the established chemotherapy, and the existing vaccine BCG, tuberculosis (TB) subsists as the chief cause of death in different parts of the...
15.
Arega A, Pattanaik K, Nayak S, Mahapatra R
Acta Trop
. 2021 Feb;
217:105870.
PMID: 33636152
Tuberculosis (TB) is a complex infectious bacterial disease, which has evolved with highly successful mechanisms to interfere with host defenses and existing classes of antibiotics to resist eradication. The single...
16.
Dhal A, Pani A, Yun S, Mahapatra R
J Biomol Struct Dyn
. 2020 Jul;
39(15):5461-5470.
PMID: 32633680
Calcium Dependent Protein Kinases are found in the Apicomplexan, algae, and plants; however, they are not reported in vertebrates and are regarded as excellent drug targets for pharmaceutical interventions. Calcium...
17.
Mahapatra R, Das M
Biosystems
. 2020 Jun;
196:104175.
PMID: 32593550
Gentianine is one of the compounds found in the plant Swertiya chirayita that is known for its antimalarial activity. However, its exact molecular mechanism of action is yet to be...
18.
Dhal A, Pani A, Mahapatra R, Yun S
Immunobiology
. 2019 Sep;
224(6):747-757.
PMID: 31522782
An immunoinformatics-based approach is explored for potential multi-subunit vaccine candidates against Cryptosporidium parvum. We performed protein structure based systematic methodology for the development of a proficient multi-subunit vaccine candidate against...
19.
Chattopadhyay S, Mahapatra R
Parasitol Res
. 2019 Sep;
118(11):3159-3171.
PMID: 31486948
Cryptosporidiosis is a significant cause of gastroenteritis in both humans and livestock in developing countries. The only FDA-approved drug available against the same is nitazoxanide, with questionable efficacy in malnourished...
20.
Rout S, Mahapatra R
Bioorg Med Chem
. 2019 Apr;
27(12):2553-2571.
PMID: 30929948
Plasmodium vivax (Pv) is the second most malaria causing pathogen among Plasmodium species. M18 aspartic aminopeptidase (M18AAP) protein is a single gene copy present in Plasmodium. This protein is functional...