Rainer Merkl
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Explore the profile of Rainer Merkl including associated specialties, affiliations and a list of published articles.
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88
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1904
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Recent Articles
1.
Kinateder T, Drexler L, Straub K, Merkl R, Sterner R
Protein Sci
. 2022 Dec;
32(1):e4536.
PMID: 36502290
The conservation of fold and chemistry of the enzymes associated with histidine biosynthesis suggests that this pathway evolved prior to the diversification of Bacteria, Archaea, and Eukaryotes. The only exception...
2.
Peterhoff D, Thalhauser S, Neckermann P, Barbey C, Straub K, Nazet J, et al.
Eur J Pharm Biopharm
. 2022 Oct;
181:88-101.
PMID: 36272655
Selective targeting of germline B cells with specifically designed germline-targeting HIV-1 envelope immunogens (GT-Env) is considered a feasible vaccination strategy to elicit broadly neutralizing antibodies (bnAbs). BnAbs are extremely valuable...
3.
Nazet J, Lang E, Merkl R
PLoS One
. 2021 Aug;
16(8):e0256691.
PMID: 34437621
Rational protein design aims at the targeted modification of existing proteins. To reach this goal, software suites like Rosetta propose sequences to introduce the desired properties. Challenging design problems necessitate...
4.
Heizinger L, Merkl R
Proteins
. 2021 May;
89(9):1167-1179.
PMID: 33957009
A comparison of protein backbones makes clear that not more than approximately 1400 different folds exist, each specifying the three-dimensional topology of a protein domain. Large proteins are composed of...
5.
Schmitz S, Ertelt M, Merkl R, Meiler J
PLoS Comput Biol
. 2021 Jan;
17(1):e1008568.
PMID: 33465067
Computational protein design has the ambitious goal of crafting novel proteins that address challenges in biology and medicine. To overcome these challenges, the computational protein modeling suite Rosetta has been...
6.
Hoffmeister H, Fuchs A, Komives E, Groebner-Ferreira R, Strobl L, Nazet J, et al.
FEBS J
. 2021 Jan;
288(13):4000-4023.
PMID: 33403747
Chromatin remodelers use the energy of ATP hydrolysis to regulate chromatin dynamics. Their impact for development and disease requires strict enzymatic control. Here, we address the differential regulability of the...
7.
Hertle R, Nazet J, Semmelmann F, Schlee S, Funke F, Merkl R, et al.
Structure
. 2020 Dec;
29(3):292-304.e3.
PMID: 33296666
The formation of specific protein complexes in a cell is a non-trivial problem given the co-existence of thousands of different polypeptide chains. A particularly difficult case are two glutamine amidotransferase...
8.
Simeth N, Kinateder T, Rajendran C, Nazet J, Merkl R, Sterner R, et al.
Chemistry
. 2020 Oct;
27(7):2439-2451.
PMID: 33078454
Light regulation of drug molecules has gained growing interest in biochemical and pharmacological research in recent years. In addition, a serious need for novel molecular targets of antibiotics has emerged...
9.
Hasler D, Meduri R, Bak M, Lehmann G, Heizinger L, Wang X, et al.
Mol Cell
. 2020 Feb;
77(5):1014-1031.e13.
PMID: 32017898
The La-related protein 7 (LARP7) forms a complex with the nuclear 7SK RNA to regulate RNA polymerase II transcription. It has been implicated in cancer and the Alazami syndrome, a...
10.
Esch R, Merkl R
BMC Bioinformatics
. 2020 Jan;
21(1):5.
PMID: 31900122
Background: The order of genes in bacterial genomes is not random; for example, the products of genes belonging to an operon work together in the same pathway. The cotranslational assembly...