Julian Nazet
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Explore the profile of Julian Nazet including associated specialties, affiliations and a list of published articles.
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12
Citations
48
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Recent Articles
1.
Kinateder T, Mayer C, Nazet J, Sterner R
Protein Sci
. 2024 Jan;
33(2):e4899.
PMID: 38284491
Advances in sequencing technologies have led to a rapid growth of public protein sequence databases, whereby the fraction of proteins with experimentally verified function continuously decreases. This problem is currently...
2.
Peterhoff D, Thalhauser S, Neckermann P, Barbey C, Straub K, Nazet J, et al.
Eur J Pharm Biopharm
. 2022 Oct;
181:88-101.
PMID: 36272655
Selective targeting of germline B cells with specifically designed germline-targeting HIV-1 envelope immunogens (GT-Env) is considered a feasible vaccination strategy to elicit broadly neutralizing antibodies (bnAbs). BnAbs are extremely valuable...
3.
Bhagat A, Schlee S, Straub K, Nazet J, Luckner P, Bruckmann A, et al.
ACS Synth Biol
. 2022 Jul;
11(8):2846-2856.
PMID: 35816663
The artificial regulation of enzymatic activity by light is an important goal of synthetic biology that can be achieved by the incorporation of light-responsive noncanonical amino acids via genetic code...
4.
Nazet J, Lang E, Merkl R
PLoS One
. 2021 Aug;
16(8):e0256691.
PMID: 34437621
Rational protein design aims at the targeted modification of existing proteins. To reach this goal, software suites like Rosetta propose sequences to introduce the desired properties. Challenging design problems necessitate...
5.
Hoffmeister H, Fuchs A, Komives E, Groebner-Ferreira R, Strobl L, Nazet J, et al.
FEBS J
. 2021 Jan;
288(13):4000-4023.
PMID: 33403747
Chromatin remodelers use the energy of ATP hydrolysis to regulate chromatin dynamics. Their impact for development and disease requires strict enzymatic control. Here, we address the differential regulability of the...
6.
Hertle R, Nazet J, Semmelmann F, Schlee S, Funke F, Merkl R, et al.
Structure
. 2020 Dec;
29(3):292-304.e3.
PMID: 33296666
The formation of specific protein complexes in a cell is a non-trivial problem given the co-existence of thousands of different polypeptide chains. A particularly difficult case are two glutamine amidotransferase...
7.
Simeth N, Kinateder T, Rajendran C, Nazet J, Merkl R, Sterner R, et al.
Chemistry
. 2020 Oct;
27(7):2439-2451.
PMID: 33078454
Light regulation of drug molecules has gained growing interest in biochemical and pharmacological research in recent years. In addition, a serious need for novel molecular targets of antibiotics has emerged...
8.
Semmelmann F, Straub K, Nazet J, Rajendran C, Merkl R, Sterner R
J Mol Biol
. 2019 May;
431(15):2718-2728.
PMID: 31121180
Allosteric communication between different subunits in metabolic enzyme complexes is of utmost physiological importance but only understood for few systems. We analyzed the structural basis of allostery in aminodeoxychorismate synthase...
9.
Hoffmeister H, Fuchs A, Strobl L, Sprenger F, Grobner-Ferreira R, Michaelis S, et al.
J Biol Chem
. 2019 Jan;
294(9):3294-3310.
PMID: 30647132
The Snf2 proteins, comprising 53 different enzymes in humans, belong to the SF2 family. Many Snf2 enzymes possess chromatin-remodeling activity, requiring a functional ATPase domain consisting of conserved motifs named...
10.
Rustler K, Mickert M, Nazet J, Merkl R, Gorris H, Konig B
Org Biomol Chem
. 2018 Sep;
16(40):7430-7437.
PMID: 30264846
Azobenzenes are of particular interest as a photochromic scaffold for biological applications because of their high fatigue resistance, their large geometrical change between extended (trans) and bent (cis) isomer, and...