Rainer Hahn
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Explore the profile of Rainer Hahn including associated specialties, affiliations and a list of published articles.
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63
Citations
340
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Recent Articles
1.
Hahn R, Berger L, Beck J, Carta G
Biotechnol Prog
. 2025 Feb;
:e3534.
PMID: 39964169
The evolution of pH and conductivity waves during elution of IgG from protein A columns is studied for the resin MabSelect PrismA as well as other commercial resins using glycine...
2.
Muller M, Gibisch M, Brocard C, Cserjan-Puschmann M, Striedner G, Hahn R
Protein Expr Purif
. 2024 Jun;
222:106537.
PMID: 38944221
Peptides are used for diagnostics, therapeutics, and as antimicrobial agents. Most peptides are produced by chemical synthesis, but recombinant production has recently become an attractive alternative due to the advantages...
3.
Gibisch M, Muller M, Tauer C, Albrecht B, Hahn R, Cserjan-Puschmann M, et al.
Microb Cell Fact
. 2024 Jun;
23(1):166.
PMID: 38840157
Background: Recombinant peptide production in Escherichia coli provides a sustainable alternative to environmentally harmful and size-limited chemical synthesis. However, in-vivo production of disulfide-bonded peptides at high yields remains challenging, due...
4.
Jurjevec A, Brocard C, Striedner G, Cserjan-Puschmann M, Toca-Herrera J, Hahn R
J Biotechnol
. 2024 Feb;
384:29-37.
PMID: 38423471
Cell disintegration and protein extraction are crucial steps in downstream process development for biopharmaceuticals produced in E. coli. In this study, we explored the extraction mechanism of polyethyleneimine (PEI) at...
5.
Gehrmann N, Daxbacher A, Hahn R
J Chromatogr B Analyt Technol Biomed Life Sci
. 2023 Dec;
1232:123989.
PMID: 38154412
Protein A chromatography remains the crucial step in mAb purification because of the high binding specificity and impurity clearance. In recent years, highly productive membrane adsorbers emerged as an alternative...
6.
Hanaee-Ahvaz H, Cserjan-Puschmann M, Mayer F, Tauer C, Albrecht B, Furtmuller P, et al.
Heliyon
. 2023 Dec;
9(12):e22463.
PMID: 38046162
Functionalization of proteins by incorporating reactive non-canonical amino acids (ncAAs) has been widely applied for numerous biological and therapeutic applications. The requirement not to lose the intrinsic properties of these...
7.
Beck J, Hochdaninger G, Carta G, Hahn R
J Chromatogr A
. 2023 Jul;
1705:464208.
PMID: 37453173
The influence of the resin structure, on the competitive binding and separation of a two-component protein mixture with anion exchange resins is evaluated using conalbumin and green fluorescent protein as...
8.
Jurjevec A, Brocard C, Striedner G, Cserjan-Puschmann M, Hahn R
J Biotechnol
. 2023 Jun;
371-372:41-49.
PMID: 37285941
We used a polycationic polymer polyethyleneimine (PEI) to develop a method to extract recombinant proteins produced in the Escherichia coli (E. coli) cytosol. Compared to high pressure homogenization, commonly used...
9.
Csukovich G, Kramer N, Pratscher B, Gotic I, Freund P, Hahn R, et al.
Int J Mol Sci
. 2023 Feb;
24(4).
PMID: 36835278
Given the high prevalence of intestinal disease in humans and animals, there is a strong need for clinically relevant models recapitulating gastrointestinal systems, ideally replacing in vivo models in accordance...
10.
Beck J, Biechele M, Repik C, Gruber P, Furtmuller P, Hahn R
J Sep Sci
. 2023 Feb;
46(8):e2200943.
PMID: 36807776
Detailed studies on the sorption behavior of plasmids on anion exchangers are rare compared to proteins. In this study, we systematically compare the elution behavior of plasmid DNA on three...