Rahul S Samant
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Explore the profile of Rahul S Samant including associated specialties, affiliations and a list of published articles.
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Articles
14
Citations
509
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Recent Articles
1.
Lord S, Johnston H, Samant R, Lai Y
J Cachexia Sarcopenia Muscle
. 2024 Sep;
15(6):2281-2294.
PMID: 39279720
Skeletal muscle is a highly adaptable tissue, finely tuned by various physiological and pathological factors. Whilst the pivotal role of skeletal muscle in overall health is widely acknowledged, unravelling the...
2.
Betancourt Moreira K, Collier M, Leitner A, Li K, Lachapel I, McCarthy F, et al.
Mol Cell
. 2023 Aug;
83(17):3123-3139.e8.
PMID: 37625406
How the essential eukaryotic chaperonin TRiC/CCT assembles from eight distinct subunits into a unique double-ring architecture remains undefined. We show TRiC assembly involves a hierarchical pathway that segregates subunits with...
3.
Samant R, Batista S, Larance M, Ozer B, Milton C, Bludau I, et al.
Mol Cell Proteomics
. 2022 Dec;
22(2):100485.
PMID: 36549590
The molecular chaperone heat shock protein 90 (HSP90) works in concert with co-chaperones to stabilize its client proteins, which include multiple drivers of oncogenesis and malignant progression. Pharmacologic inhibitors of...
4.
Johnston H, Yadav K, Kirkpatrick J, Biggs G, Oxley D, Kramer H, et al.
Anal Chem
. 2022 Jul;
94(29):10320-10328.
PMID: 35848328
Complete, reproducible extraction of protein material is essential for comprehensive and unbiased proteome analyses. A current gold standard is single-pot, solid-phase-enhanced sample preparation (SP3), in which organic solvent and magnetic...
5.
Johnston H, Samant R
FEBS J
. 2020 Nov;
288(15):4464-4487.
PMID: 33135311
Protein misfolding is a major driver of ageing-associated frailty and disease pathology. Although all cells possess multiple, well-characterised protein quality control systems to mitigate the toxicity of misfolded proteins, how...
6.
Samant R, Masto V, Frydman J
Genes Dev
. 2019 Aug;
33(15-16):1027-1030.
PMID: 31371460
Gene dosage alterations caused by aneuploidy are a common feature of most cancers yet pose severe proteotoxic challenges. Therefore, cells have evolved various dosage compensation mechanisms to limit the damage...
7.
Samant R, Frydman J
Methods Enzymol
. 2019 Mar;
619:27-45.
PMID: 30910025
Protein misfolding in the cell is linked to an array of diseases, including cancers, cardiovascular disease, type II diabetes, and numerous neurodegenerative disorders. Therefore, investigating cellular pathways by which misfolded...
8.
Samant R, Livingston C, Sontag E, Frydman J
Nature
. 2018 Nov;
563(7731):407-411.
PMID: 30429547
Protein misfolding is linked to a wide array of human disorders, including Alzheimer's disease, Parkinson's disease and type II diabetes. Protective cellular protein quality control (PQC) mechanisms have evolved to...
9.
Sontag E, Samant R, Frydman J
Annu Rev Biochem
. 2017 May;
86:97-122.
PMID: 28489421
A healthy proteome is essential for cell survival. Protein misfolding is linked to a rapidly expanding list of human diseases, ranging from neurodegenerative diseases to aging and cancer. Many of...
10.
Dale T, Clarke P, Esdar C, Waalboer D, Adeniji-Popoola O, Ortiz-Ruiz M, et al.
Nat Chem Biol
. 2015 Oct;
11(12):973-980.
PMID: 26502155
There is unmet need for chemical tools to explore the role of the Mediator complex in human pathologies ranging from cancer to cardiovascular disease. Here we determine that CCT251545, a...