Rafik M Ghobrial
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Explore the profile of Rafik M Ghobrial including associated specialties, affiliations and a list of published articles.
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98
Citations
2019
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Recent Articles
1.
Xiao X, Du Y, Sun S, Su X, Xing J, Wang G, et al.
J Clin Invest
. 2024 Dec;
135(4).
PMID: 39739423
T cells have a remarkable capacity to clonally expand, a process that is intricately linked to their effector activities. As vigorously proliferating T cell also incur substantial DNA lesions, how...
2.
Kloc M, Halasa M, Ghobrial R
Cell Immunol
. 2024 Apr;
399-400:104825.
PMID: 38648700
Macrophage niches are the anatomical locations within organs or tissues consisting of various cells, intercellular and extracellular matrix, transcription factors, and signaling molecules that interact to influence macrophage self-maintenance, phenotype,...
3.
Halasa M, Uosef A, Ubelaker H, Subuddhi A, Mysore K, Kubiak J, et al.
Cell Tissue Res
. 2024 Apr;
397(1):51-60.
PMID: 38625373
Gadolinium is a component of the MRI contrast agent Dotarem. Although Dotarem is the least toxic among MRI contrasts used, gadolinium present in Dotarem accumulates for many years in various...
4.
Kloc M, Halasa M, Kubiak J, Ghobrial R
Int J Mol Sci
. 2024 Jan;
25(2).
PMID: 38256145
While the vertebrate immune system consists of innate and adaptive branches, invertebrates only have innate immunity. This feature makes them an ideal model system for studying the cellular and molecular...
5.
Zou D, Yin Z, Yi S, Wang G, Guo Y, Xiao X, et al.
Nat Immunol
. 2024 Jan;
25(1):66-76.
PMID: 38168955
CD4 T cells are central to various immune responses, but the molecular programs that drive and maintain CD4 T cell immunity are not entirely clear. Here we identify a stem-like...
6.
Kloc M, Uosef A, Ubelaker H, Kubiak J, Ghobrial R
Stem Cell Investig
. 2023 Apr;
10:9.
PMID: 37077316
Like all immune cells, macrophages do not act autonomously but in unison with other immune cells, surrounding tissues, and the niche they occupy. Constant exchange of information between cellular and...
7.
Subuddhi A, Uosef A, Zou D, Ubelaker H, Ghobrial R, Kloc M
Int Immunopharmacol
. 2023 Mar;
118:110017.
PMID: 36931169
Macrophages play a crucial role in, the currently uncurable, chronic rejection of transplants. In rodent transplantation models, inhibition of the RhoA/Rock pathway disrupts actin-related functions of macrophages, preventing them from...
8.
Abboud K, Umoru G, Esmail A, Abudayyeh A, Murakami N, Al-Shamsi H, et al.
Cancers (Basel)
. 2023 Mar;
15(5).
PMID: 36900226
The rationale for administering immune checkpoint inhibitors (ICIs) in the adjuvant setting is to eradicate micro-metastases and, ultimately, prolong survival. Thus far, clinical trials have demonstrated that 1-year adjuvant courses...
9.
Verna E, Phipps M, Halazun K, Markovic D, Florman S, Haydel B, et al.
Liver Transpl
. 2023 Jan;
29(1):34-47.
PMID: 36630156
NAFLD will soon be the most common indication for liver transplantation (LT). In NAFLD, HCC may occur at earlier stages of fibrosis and present with more advanced tumor stage, raising...
10.
Kloc M, Kubiak J, Zdanowski R, Ghobrial R
Int J Mol Sci
. 2023 Jan;
24(1).
PMID: 36613481
Immunological memory is a crucial part of the immune defense that allows organisms to respond against previously encountered pathogens or other harmful factors. Immunological memory is based on the establishment...