Rafik M Ghobrial
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Explore the profile of Rafik M Ghobrial including associated specialties, affiliations and a list of published articles.
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98
Citations
2019
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Recent Articles
11.
Kloc M, Kubiak J, Ghobrial R
Int J Mol Sci
. 2022 Nov;
23(22).
PMID: 36430636
Atherosclerosis is an inflammatory disease depending on the buildup, called plaque, of lipoproteins, cholesterol, extracellular matrix elements, and various types of immune and non-immune cells on the artery walls. Plaque...
12.
Wen M, Ying Y, Xiao X, Arnold P, Wang G, Chu X, et al.
JCI Insight
. 2022 Oct;
7(23).
PMID: 36256455
BRD4 is a bromodomain extraterminal domain family member and functions primarily as a chromatin reader regulating genes involved in cell-fate decisions. Here, we bred Brd4fl/fl Ox40-Cre mice in which Brd4...
13.
Kloc M, Uosef A, Subuddhi A, Kubiak J, Piprek R, Ghobrial R
Biology (Basel)
. 2022 Jul;
11(8).
PMID: 35892977
This review introduces the subject of senescence, aging, and the formation of senescent multinucleated giant cells. We define senescence and aging and describe how molecular and cellular senescence leads to...
14.
Kloc M, Subuddhi A, Uosef A, Kubiak J, Ghobrial R
Int J Mol Sci
. 2022 Jun;
23(12).
PMID: 35742997
Cell fusion (fusogenesis) occurs in natural and pathological conditions in prokaryotes and eukaryotes. Cells of monocyte-macrophage lineage are highly fusogenic. They create syncytial multinucleated giant cells (MGCs) such as osteoclasts...
15.
Abdelrahim M, Esmail A, Umoru G, Westhart K, Abudayyeh A, Saharia A, et al.
Curr Oncol
. 2022 Jun;
29(6):4267-4273.
PMID: 35735450
Systemic combination therapy of immune checkpoint inhibitors and vascular endothelial growth factors have provided the basis for improved outcomes in select patients with unresectable or metastatic hepatocellular carcinoma. However, for...
16.
Abdelrahim M, Esmail A, Xu J, Umoru G, Al-Rawi H, Saharia A, et al.
Front Oncol
. 2022 Jun;
12:908687.
PMID: 35719974
Background: Cholangiocarcinoma management is constantly being updated in view of existing evidence in order to establish practice guidelines and consensus statements. However, the available treatment guidelines to optimize outcomes for...
17.
Abdelrahim M, Al-Rawi H, Esmail A, Xu J, Umoru G, Ibnshamsah F, et al.
Curr Oncol
. 2022 May;
29(5):3585-3594.
PMID: 35621680
Background: The management of cholangiocarcinoma is continually reviewed on a current evidence basis to develop practice guidelines and consensus statements. However, the standardized treatment guidelines are still unclear for cholangiocarcinoma...
18.
Wang G, Xiao X, Wang Y, Chu X, Dou Y, Minze L, et al.
Cell Mol Immunol
. 2022 Mar;
19(6):687-701.
PMID: 35322175
The RNA helicase DHX15 is widely expressed in immune cells and traditionally thought to be an RNA splicing factor or a viral RNA sensor. However, the role of DHX15 in...
19.
Kloc M, Kubiak J, Ghobrial R
Dev Biol
. 2022 Mar;
486:15-25.
PMID: 35321809
Typically, all cells of a given organism have the same set of chromosomes. However, there are exceptions to this rule, and in many organisms, the somatic cells and germ cells,...
20.
Chanana P, Uosef A, Vaughn N, Suarez-Villagran M, Ghobrial R, Kloc M, et al.
Cells
. 2022 Mar;
11(5).
PMID: 35269379
Magnetic resonance imaging (MRI) is widely used in diagnostic medicine. MRI uses the static magnetic field to polarize nuclei spins, fast-switching magnetic field gradients to generate temporal and spatial resolution,...