Rafael Tapia-Rojo
Overview
Explore the profile of Rafael Tapia-Rojo including associated specialties, affiliations and a list of published articles.
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24
Citations
242
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Recent Articles
1.
Tapia-Rojo R
Biophys Rev
. 2025 Mar;
17(1):25-44.
PMID: 40060007
Single-molecule magnetic tweezers have recently emerged as a powerful technique for measuring the equilibrium dynamics of individual proteins under force. In magnetic tweezers, a single protein is tethered between a...
2.
Panagaki F, Tapia-Rojo R, Zhu T, Milmoe N, Paracuellos P, Board S, et al.
Nat Phys
. 2024 Jul;
20(7):1180-1193.
PMID: 39036650
The nuclear pore complex regulates nucleocytoplasmic transport by means of a tightly synchronized suite of biochemical reactions. The physicochemical properties of the translocating cargos are emerging as master regulators of...
3.
Tapia-Rojo R
Methods Enzymol
. 2024 Mar;
694:83-107.
PMID: 38492959
Mechanical forces are critical to protein function across many biological contexts-from bacterial adhesion to muscle mechanics and mechanotransduction processes. Hence, understanding how mechanical forces govern protein activity has developed into...
4.
Tapia-Rojo R, Mora M, Garcia-Manyes S
Nat Protoc
. 2024 Mar;
19(6):1779-1806.
PMID: 38467905
The reversible unfolding and refolding of proteins is a regulatory mechanism of tissue elasticity and signalling used by cells to sense and adapt to extracellular and intracellular mechanical forces. However,...
5.
Tapia-Rojo R, Alonso-Caballero A, Badilla C, Fernandez J
Biophys J
. 2024 Feb;
123(7):814-823.
PMID: 38409780
The classical "one sequence, one structure, one function" paradigm has shaped much of our intuition of how proteins work inside the cell. Partially due to the insight provided by bulk...
6.
Darrigrand J, Salowka A, Torres-Cano A, Tapia-Rojo R, Zhu T, Garcia-Manyes S, et al.
Dev Cell
. 2024 Jan;
59(3):326-338.e5.
PMID: 38237591
During organ formation, progenitor cells need to acquire different cell identities and organize themselves into distinct structural units. How these processes are coordinated and how tissue architecture(s) is preserved despite...
7.
Mora M, Tapia-Rojo R, Garcia-Manyes S
Methods Mol Biol
. 2023 Oct;
2694:339-354.
PMID: 37824012
Single-molecule atomic force microscopy (AFM) allows capturing the conformational dynamics of an individual molecule under force. In this chapter, we describe a protocol for conducting a protein nanomechanical experiment using...
8.
Bernabe-Rubio M, Ali S, Bhosale P, Goss G, Mobasseri S, Tapia-Rojo R, et al.
Nat Cell Biol
. 2023 Sep;
25(10):1426-1438.
PMID: 37735598
Dedifferentiation is the process by which terminally differentiated cells acquire the properties of stem cells. During mouse skin wound healing, the differentiated Gata6-lineage positive cells of the sebaceous duct are...
9.
Franz F, Tapia-Rojo R, Winograd-Katz S, Boujemaa-Paterski R, Li W, Unger T, et al.
Nat Commun
. 2023 Jul;
14(1):4311.
PMID: 37463895
The talin-vinculin axis is a key mechanosensing component of cellular focal adhesions. How talin and vinculin respond to forces and regulate one another remains unclear. By combining single-molecule magnetic tweezers...
10.
Tapia-Rojo R, Mora M, Board S, Walker J, Boujemaa-Paterski R, Medalia O, et al.
Nat Phys
. 2023 Jan;
19(1):52-60.
PMID: 36660164
Statistical mechanics can describe the major conformational ensembles determining the equilibrium free-energy landscape of a folding protein. The challenge is to capture the full repertoire of low-occurrence conformations separated by...