Rafael Dariolli
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Explore the profile of Rafael Dariolli including associated specialties, affiliations and a list of published articles.
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40
Citations
369
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Recent Articles
1.
Dariolli R, Nir R, Mushlam T, Souza G, Farmer S, Batista Jr M
SLAS Discov
. 2025 Jan;
31:100218.
PMID: 39870353
Obesity and type 2 diabetes (T2D) are strongly linked to abnormal adipocyte metabolism and adipose tissue (AT) dysfunction. However, existing adipose tissue models have limitations, particularly in the stable culture...
2.
Gonzalez D, Dariolli R, Moyett J, Song S, Shewale B, Bliley J, et al.
bioRxiv
. 2024 Oct;
PMID: 39386729
Cardiac Purkinje fibers form the most distal part of the ventricular conduction system. They coordinate contraction and play a key role in ventricular arrhythmias. While many cardiac cell types can...
3.
Rodriguez N, Patel N, Dariolli R, Ng S, Aleman A, Gong J, et al.
Circ Arrhythm Electrophysiol
. 2024 Feb;
17(4):e012022.
PMID: 38415356
Background: Germline gain-of-function pathogenic variants cause Costello syndrome (CS). During early childhood, 50% of patients develop multifocal atrial tachycardia, a treatment-resistant tachyarrhythmia of unknown pathogenesis. This study investigated how overactive...
4.
Shim J, Xiong Y, Dhanan P, Dariolli R, Azeloglu E, Hu B, et al.
Front Pharmacol
. 2023 Apr;
14:1158222.
PMID: 37101545
Tyrosine kinase inhibitor drugs (TKIs) are highly effective cancer drugs, yet many TKIs are associated with various forms of cardiotoxicity. The mechanisms underlying these drug-induced adverse events remain poorly understood....
5.
Munoz J, Dariolli R, da Silva C, Neri E, Valadao I, Turaca L, et al.
Stem Cell Res Ther
. 2022 Sep;
13(1):437.
PMID: 36056380
Background: Human-induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CM) are a promising disease model, even though hiPSC-CMs cultured for extended periods display an undifferentiated transcriptional landscape. MiRNA-target gene interactions contribute to fine-tuning...
6.
Medrano R, Salles T, Dariolli R, Antunes F, Feitosa V, Hunger A, et al.
Sci Rep
. 2022 Aug;
12(1):13636.
PMID: 35948616
Balancing safety and efficacy is a major consideration for cancer treatments, especially when combining cancer immunotherapy with other treatment modalities such as chemotherapy. Approaches that induce immunogenic cell death (ICD)...
7.
Wickramasinghe N, Sachs D, Shewale B, Gonzalez D, Dhanan-Krishnan P, Torre D, et al.
Cell Stem Cell
. 2022 Mar;
29(4):559-576.e7.
PMID: 35325615
Pluripotent stem-cell-derived cardiomyocytes (PSC-CMs) provide an unprecedented opportunity to study human heart development and disease, but they are functionally and structurally immature. Here, we induce efficient human PSC-CM (hPSC-CM) maturation...
8.
Peron D, Prates R, Antonio E, Teixeira I, de Oliveira H, Mansano B, et al.
J Clin Periodontol
. 2022 Jan;
49(5):506-517.
PMID: 35066916
Aim: To evaluate whether Porphyromonas gingivalis (P. gingivalis) inoculation could induce cardiac remodelling in rats. Materials And Methods: The study was conducted on 33 Wistar rats, which were distributed in...
9.
Salerno J, Torquato T, Temerozo J, Goto-Silva L, Karmirian K, Mendes M, et al.
PeerJ
. 2022 Jan;
9:e12595.
PMID: 35036128
SARS-CoV-2 infects cardiac cells and causes heart dysfunction. Conditions such as myocarditis and arrhythmia have been reported in COVID-19 patients. The Sigma-1 receptor (S1R) is a ubiquitously expressed chaperone that...
10.
Schaniel C, Dhanan P, Hu B, Xiong Y, Raghunandan T, Gonzalez D, et al.
Stem Cell Reports
. 2021 Nov;
16(12):3036-3049.
PMID: 34739849
A library of well-characterized human induced pluripotent stem cell (hiPSC) lines from clinically healthy human subjects could serve as a useful resource of normal controls for in vitro human development,...