Radhakrishnan Mahadevan
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Explore the profile of Radhakrishnan Mahadevan including associated specialties, affiliations and a list of published articles.
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125
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2445
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Recent Articles
1.
Xu Z, Barghout R, Wu J, Garg D, Song Y, Mahadevan R
bioRxiv
. 2025 Feb;
PMID: 39896624
Recent advancements in deep learning have enabled functional annotation of genome sequences, facilitating the discovery of new enzymes and metabolites. However, accurately predicting compound-protein interactions (CPI) from sequences remains challenging...
2.
Bulka O, Mahadevan R, Edwards E
Microb Genom
. 2024 Nov;
10(11).
PMID: 39565095
is a genus of organohalide-respiring bacteria that is recognized for its fastidious growth using reductive dehalogenases (RDases). In the SC05 culture, however, a population also mineralizes dichloromethane (DCM) produced by...
3.
Carlson R, Beck A, Benitez M, Harcombe W, Mahadevan R, Gedeon T
bioRxiv
. 2024 Sep;
PMID: 39229203
A metabolic theory is presented for predicting maximum growth rate, overflow metabolism, respiration efficiency, and maintenance energy flux based on the intersection of cell geometry, membrane protein crowding, and metabolism....
4.
Agena E, Gois I, Bowers C, Mahadevan R, Scarborough M, Lawson C
J Ind Microbiol Biotechnol
. 2024 Aug;
51.
PMID: 39090985
One-sentence Summary: In this work, the authors use constraint-based metabolic modelling and enzyme cost minimization to assess the feasibility of using metabolic engineering to expand the product spectrum of anaerobic...
5.
Choudhary R, Mahadevan R
ACS Med Chem Lett
. 2024 Jul;
15(7):1057-1070.
PMID: 39015268
In this study, we introduce the Framework for Optimized Customizable User-Informed Synthesis (FOCUS), a generative machine learning model tailored for drug discovery. FOCUS integrates domain expertise and uses Proximal Policy...
6.
Pham C, Stogios P, Savchenko A, Mahadevan R
ACS Synth Biol
. 2024 Jun;
13(7):2246-2252.
PMID: 38875315
Transcription factor (TF)-based biosensors are useful synthetic biology tools for applications in a variety of areas of biotechnology. A major challenge of biosensor circuits is the limited repertoire of identified...
7.
Bulka O, Picott K, Mahadevan R, Edwards E
Appl Environ Microbiol
. 2024 May;
90(6):e0073224.
PMID: 38819127
Importance: Chloroform (CF) and dichloromethane (DCM) are regulated groundwater contaminants. A cost-effective approach to remove these pollutants from contaminated groundwater is to employ microbes that transform CF and DCM as...
8.
Pham C, Stogios P, Savchenko A, Mahadevan R
Comput Struct Biotechnol J
. 2024 May;
23:2211-2219.
PMID: 38817964
Transcription factor (TF)-based biosensors that connect small-molecule sensing with readouts such as fluorescence have proven to be useful synthetic biology tools for applications in biotechnology. However, the development of specific...
9.
Choudhary R, Mahadevan R
Biophys J
. 2024 May;
123(18):2974-2995.
PMID: 38733081
There have been a growing number of computational strategies to aid in the design of synthetic microbial consortia. A framework to identify regions in parametric space to maximize two essential...
10.
Pham C, Nasr M, Skarina T, Di Leo R, Kwan D, Martin V, et al.
FEBS J
. 2024 May;
291(15):3481-3498.
PMID: 38696354
Prokaryotic transcription factors (TFs) regulate gene expression in response to small molecules, thus representing promising candidates as versatile small molecule-detecting biosensors valuable for synthetic biology applications. The engineering of such...