Rachid Hamid
Overview
Explore the profile of Rachid Hamid including associated specialties, affiliations and a list of published articles.
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Articles
10
Citations
186
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0
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Recent Articles
1.
Kim J, Okamoto H, Huang Z, Anguiano G, Chen S, Liu Q, et al.
Cell Metab
. 2017 Jun;
25(6):1348-1361.e8.
PMID: 28591637
Glucagon supports glucose homeostasis by stimulating hepatic gluconeogenesis, in part by promoting the uptake and conversion of amino acids into gluconeogenic precursors. Genetic disruption or pharmacologic inhibition of glucagon signaling...
2.
Ren Y, Guo L, Tang X, Apparsundaram S, Kitson C, Deguzman J, et al.
Microvasc Res
. 2012 Oct;
85:59-67.
PMID: 23084965
Lysophosphatidic acid (LPA) is a class of bioactive lyso-phospholipid that mediates most of its biological effects through a family of G protein-coupled receptors of which six have been identified. The...
3.
Qian Y, Hamilton M, Sidduri A, Gabriel S, Ren Y, Peng R, et al.
J Med Chem
. 2012 Aug;
55(17):7920-39.
PMID: 22894757
Lysophosphatidic acid is a class of bioactive phospholipid that mediates most of its biological effects through LPA receptors, of which six isoforms have been identified. The recent results from LPA1...
4.
Coffman F, Hamid R, Cohen M, Garippa R, Cohen S
Anal Cell Pathol (Amst)
. 2011 Oct;
34(5):225-34.
PMID: 21988886
Despite significant differences in genetic profiles, cancer cells share common phenotypic properties, including membrane-associated changes that facilitate invasion and metastasis. The Corning Epic optical biosensor was used to monitor dynamic...
5.
Firooznia F, Cheung A, Brinkman J, Grimsby J, Gubler M, Hamid R, et al.
Bioorg Med Chem Lett
. 2011 Mar;
21(7):1933-6.
PMID: 21388809
The highly potent but modestly selective N-(2-amino-4-methoxy-benzothiazol-7-yl)-N-ethyl-acetamide derivative 2 was selected as the starting point for the design of novel selective A(2B) antagonists, due to its excellent potency, and good...
6.
Cheung A, Brinkman J, Firooznia F, Flohr A, Grimsby J, Gubler M, et al.
Bioorg Med Chem Lett
. 2010 Jun;
20(14):4140-6.
PMID: 20541935
7-N-Acetamide-4-methoxy-2-aminobenzothiazole 4-fluorobenzamide (compound 1) was chosen as a drug-like and non-xanthine based starting point for the discovery of A(2B) receptor antagonists because of its slight selectivity against A(1) and A(2A)...
7.
Goodnow Jr R, Hicks A, Sidduri A, Kowalczyk A, Dominique R, Qiao Q, et al.
J Med Chem
. 2010 Apr;
53(9):3502-16.
PMID: 20380377
The inhibition of LTB(4) binding to and activation of G-protein-coupled receptors BLT1 and BLT2 is the premise of a treatment for several inflammatory diseases. In a lead optimization effort starting...
8.
Hicks A, Goodnow Jr R, Cavallo G, Tannu S, Ventre J, Lavelle D, et al.
Prostaglandins Other Lipid Mediat
. 2010 Mar;
92(1-4):33-43.
PMID: 20214997
Asthma, chronic obstructive pulmonary disease (COPD) and acute lung injury/acute respiratory distress syndrome (ALI/ARDS) are characterized by neutrophilic inflammation and elevated levels of leukotriene B4 (LTB4). However, the exact role...
9.
Moaddel R, Hamid R, Patel S, Bullock P, Wainer I
Anal Chim Acta
. 2007 Aug;
578(1):25-30.
PMID: 17723691
The Caco-2 cell monolayer model was used to classify 13 compounds as P-glycoprotein (Pgp) substrates or non-substrates. The apparent permeability coefficients (Papp) in the basal-to-apical direction (Papp(B-A)) and in the...
10.
DePinto W, Chu X, Yin X, Smith M, Packman K, Goelzer P, et al.
Mol Cancer Ther
. 2006 Nov;
5(11):2644-58.
PMID: 17121911
The cyclin-dependent protein kinases are key regulators of cell cycle progression. Aberrant expression or altered activity of distinct cyclin-dependent kinase (CDK) complexes results in escape of cells from cell cycle...