Rachel L Flynn
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Explore the profile of Rachel L Flynn including associated specialties, affiliations and a list of published articles.
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7
Citations
63
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Recent Articles
1.
Mori J, Keegan J, Flynn R, Heaphy C
J Clin Pathol
. 2023 Oct;
77(2):82-86.
PMID: 37890990
Telomere maintenance and elongation allows cells to gain replicative immortality and evade cellular senescence during cancer development. While most cancers use telomerase to maintain telomere lengths, a subset of cancers...
2.
Zamalloa L, Pruitt M, Hermance N, Gali H, Flynn R, Manning A
Life Sci Alliance
. 2023 Sep;
6(12).
PMID: 37704395
The retinoblastoma tumor suppressor protein (RB) interacts physically and functionally with a number of epigenetic modifying enzymes to control transcriptional regulation, respond to replication stress, promote DNA damage response and...
3.
Carson L, Flynn R
Curr Opin Pharmacol
. 2023 May;
70:102380.
PMID: 37149932
The alternative lengthening of telomeres (ALT) pathway is a telomere elongation mechanism found in a small but often aggressive subset of cancers. Dependent on break-induced replication, telomere extension in ALT-positive...
4.
Zamalloa L, Pruitt M, Hermance N, Gali H, Flynn R, Manning A
bioRxiv
. 2023 Mar;
PMID: 36993348
The retinoblastoma tumor suppressor protein (RB) interacts physically and functionally with a number of epigenetic modifying enzymes to control transcriptional regulation, respond to replication stress, promote DNA damage response and...
5.
Floro J, Dai A, Metzger A, Mora-Martin A, Ganem N, Cifuentes D, et al.
Nucleic Acids Res
. 2021 Aug;
49(16):9424-9443.
PMID: 34365507
RNA provides the framework for the assembly of some of the most intricate macromolecular complexes within the cell, including the spliceosome and the mature ribosome. The assembly of these complexes...
6.
Flynn R, Heaphy C
Trends Genet
. 2019 Sep;
35(11):783-785.
PMID: 31526614
Cancer cells maintain telomere lengths through telomerase activity or by alternative lengthening of telomeres (ALT). Using an engineered model system, a recent study by Min et al. reveals that the...
7.
Panier S, Maric M, Hewitt G, Mason-Osann E, Gali H, Dai A, et al.
Mol Cell
. 2019 Aug;
76(1):27-43.e11.
PMID: 31447390
Cancer cells acquire unlimited proliferative capacity by either re-expressing telomerase or inducing alternative lengthening of telomeres (ALT), which relies on telomere recombination. Here, we show that ALT recombination requires coordinate...