Amity L Manning
Overview
Explore the profile of Amity L Manning including associated specialties, affiliations and a list of published articles.
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32
Citations
2072
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Recent Articles
1.
Zamalloa L, Pruitt M, Hermance N, Gali H, Flynn R, Manning A
Life Sci Alliance
. 2023 Sep;
6(12).
PMID: 37704395
The retinoblastoma tumor suppressor protein (RB) interacts physically and functionally with a number of epigenetic modifying enzymes to control transcriptional regulation, respond to replication stress, promote DNA damage response and...
2.
Mercadante D, Aaron W, Olson S, Manning A
Mol Biol Cell
. 2023 Apr;
34(6):ar63.
PMID: 37017483
During cell division, the microtubule nucleating and organizing organelle, known as the centrosome, is a critical component of the mitotic spindle. In cells with two centrosomes, each centrosome functions as...
3.
Zamalloa L, Pruitt M, Hermance N, Gali H, Flynn R, Manning A
bioRxiv
. 2023 Mar;
PMID: 36993348
The retinoblastoma tumor suppressor protein (RB) interacts physically and functionally with a number of epigenetic modifying enzymes to control transcriptional regulation, respond to replication stress, promote DNA damage response and...
4.
Crowley E, Hermance N, Herlihy C, Manning A
Mol Cancer Ther
. 2022 Jul;
21(10):1583-1593.
PMID: 35905505
Numerical chromosome instability, or nCIN, defined as the high frequency of whole chromosome gains and losses, is prevalent in many solid tumors. nCIN has been shown to promote intratumor heterogeneity...
5.
Rajasekaran S, Khan E, Ching S, Khan M, Siddiqui J, Gradia D, et al.
Nucleic Acids Res
. 2022 Jun;
50(12):7048-7066.
PMID: 35736218
DICER1 syndrome is a cancer pre-disposition disorder caused by mutations that disrupt the function of DICER1 in miRNA processing. Studying the molecular, cellular and oncogenic effects of these mutations can...
6.
Herlihy C, Hahn S, Hermance N, Crowley E, Manning A
J Cell Sci
. 2021 Aug;
134(15).
PMID: 34342353
Centromere structure and function are defined by the epigenetic modification of histones at centromeric and pericentromeric chromatin. The constitutive heterochromatin found at pericentromeric regions is highly enriched for H3K9me3 and...
7.
Mercadante D, Manning A, Olson S
Biophys J
. 2021 Jul;
120(15):3192-3210.
PMID: 34197801
Proper formation and maintenance of the mitotic spindle is required for faithful cell division. Although much work has been done to understand the roles of the key molecular components of...
8.
Quinton R, DiDomizio A, Vittoria M, Kotynkova K, Ticas C, Patel S, et al.
Nature
. 2021 May;
593(7860):E15.
PMID: 33976417
No abstract available.
9.
Quinton R, DiDomizio A, Vittoria M, Kotynkova K, Ticas C, Patel S, et al.
Nature
. 2021 Jan;
590(7846):492-497.
PMID: 33505027
Whole-genome doubling (WGD) is common in human cancers, occurring early in tumorigenesis and generating genetically unstable tetraploid cells that fuel tumour development. Cells that undergo WGD (WGD cells) must adapt...
10.
Brunner A, Blonquist T, DeAngelo D, McMasters M, Fell G, Hermance N, et al.
Lancet Haematol
. 2019 Dec;
7(2):e122-e133.
PMID: 31837959
Background: Increased aurora A kinase (AAK) expression occurs in acute myeloid leukaemia; AAK inhibition is a promising therapeutic target in this disease. We therefore aimed to assess the activity of...