Rachael W Sirianni
Overview
Explore the profile of Rachael W Sirianni including associated specialties, affiliations and a list of published articles.
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36
Citations
581
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Recent Articles
11.
Sandberg D, Kharas N, Yu B, Janssen C, Trimble A, Ballester L, et al.
J Neurosurg Pediatr
. 2020 May;
26(2):127-135.
PMID: 32357333
Objective: Chemotherapy infusions directly into the fourth ventricle may play a role in treating malignant fourth-ventricular tumors. This study tested the safety and pharmacokinetics of short-term and long-term administration of...
12.
Medina D, Chung E, Teague C, Bowser R, Sirianni R
Front Bioeng Biotechnol
. 2020 Apr;
8:224.
PMID: 32292776
Dysregulation of the retinoic acid (RA) signaling pathway is observed in amyotrophic lateral sclerosis (ALS) and other neurodegenerative disorders. Here, we investigated the therapeutic potential of retinoid activation via the...
13.
Chung E, Cotter J, Prakapenka A, Cook R, DiPerna D, Sirianni R
Pharmaceutics
. 2020 Jan;
12(2).
PMID: 31991664
Alternative routes of administration are one approach that could be used to bypass the blood-brain barrier (BBB) for effective drug delivery to the central nervous system (CNS). Here, we focused...
14.
Sandberg D, Yu B, Patel R, Hagan J, Miesner E, Sabin J, et al.
J Neurooncol
. 2018 Nov;
141(2):449-457.
PMID: 30460634
Background: DNA methylation inhibitors are logical therapeutic candidates for ependymomas originating in the posterior fossa of the brain. Our objective was to test the safety of infusing 5-Azacytidine (5-AZA), a...
15.
DiPerna D, Prakapenka A, Chung E, Sirianni R
Methods Mol Biol
. 2018 Jul;
1831:191-199.
PMID: 30051433
Biodistribution is a valuable technique used to determine payload delivery from nanocarrier to organs of interest in preclinical models. Fluorescent probes can be used as drug surrogates, providing indirect but...
16.
Householder K, DiPerna D, Chung E, Luning A, Nguyen D, Stabenfeldt S, et al.
Colloids Surf B Biointerfaces
. 2018 Mar;
166:37-44.
PMID: 29533842
Histone deacetylases (HDACs) are known to be key enzymes in cancer development and progression through their modulation of chromatin structure and the expression and post-translational modification of numerous proteins. Aggressive...
17.
Prakapenka A, Hiroi R, Quihuis A, Carson C, Patel S, Berns-Leone C, et al.
Neurobiol Aging
. 2018 Jan;
64:1-14.
PMID: 29316527
Most estrogen-based hormone therapies are administered in combination with a progestogen, such as Levonorgestrel (Levo). Individually, the estrogen 17β-estradiol (E2) and Levo can improve cognition in preclinical models. However, although...
18.
Heffernan J, McNamara J, Borwege S, Vernon B, Sanai N, Mehta S, et al.
Biomaterials
. 2017 Aug;
143:149-158.
PMID: 28802102
Glioblastoma (GBM) is the most common adult primary brain tumor, and the 5-year survival rate is less than 5%. GBM malignancy is driven in part by a population of GBM...
19.
Moutal A, Villa L, Yeon S, Householder K, Park K, Sirianni R, et al.
Mol Neurobiol
. 2017 Jun;
55(5):4403-4416.
PMID: 28660485
Glioblastoma (GBM) is an aggressive primary brain tumor. The rapid growth and the privileged provenance of the tumor within the brain contribute to its aggressivity and poor therapeutic targeting. A...
20.
Prakapenka A, Bimonte-Nelson H, Sirianni R
Ann Biomed Eng
. 2017 Jun;
45(7):1697-1709.
PMID: 28634732
With menopause, circulating levels of 17β-estradiol (E2) markedly decrease. E2-based hormone therapy is prescribed to alleviate symptoms associated with menopause. E2 is also recognized for its beneficial effects in the...