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Ian Daniels

Explore the profile of Ian Daniels including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 29
Citations 314
Followers 0
Related Specialties
Oncology
Allergy & Immunology
General Surgery
Top 10 Co-Authors
Peter Symonds
Lindy G Durrant
Mohamed Gijon
Victoria A Brentville
Rachael L Metheringham
Wei Xue
Andrew P Haynes
Sabaria Shah
Poonam Vaghela
Neil Smart
Published In
Oncoimmunology
Br J Haematol
J Immunother Cancer
Front Immunol
Dis Colon Rectum
Affiliations
Soon will be listed here.
Recent Articles
1.
Immune responses to citrullinated and homocitrullinated peptides in healthy donors are not restricted to the HLA SE shared allele and can be selected into the memory pool
Choudhury R, Daniels I, Vaghela P, Atabani S, Kirk T, Symonds P, et al.
Immunology . 2023 Apr; 169(4):467-486. PMID: 37055914
Citrullination and homocitrullination are stress induced post-translational modifications (siPTMs) which can be recognized by T cells. Peripheral blood mononuclear cells isolated from healthy donors and rheumatoid arthritis (RA) patients were...
2.
Citrullinated glucose-regulated protein 78 is a candidate target for melanoma immunotherapy
Brentville V, Symonds P, Chua J, Skinner A, Daniels I, Cook K, et al.
Front Immunol . 2022 Dec; 13:1066185. PMID: 36544781
Introduction: Post translational modification of proteins plays a significant role in immune recognition. In particular the modification of arginine to citrulline which is mediated by PAD enzymes is increased during...
3.
Vaccine Can Induce CD4-Mediated Responses to Homocitrullinated Peptides Multiple HLA-Types and Confer Anti-Tumor Immunity
Cook K, Xue W, Atabani S, Symonds P, Al Omari A, Daniels I, et al.
Front Immunol . 2022 Apr; 13:873947. PMID: 35464453
Homocitrullination is the post translation modification (PTM) of the amino acid lysine to homocitrulline also referred to as carbamylation. This PTM has mainly been studied in relation to autoimmune diseases...
4.
PAD-2-mediated citrullination of nucleophosmin provides an effective target for tumor immunotherapy
Choudhury R, Symonds P, Paston S, Daniels I, Cook K, Gijon M, et al.
J Immunother Cancer . 2022 Feb; 10(2). PMID: 35140112
Background: The enzymatic conversion of arginine to citrulline is involved in gene and protein regulation and in alerting the immune system to stressed cells, including tumor cells. Nucleophosmin (NPM) is...
5.
Homocitrullination of lysine residues mediated by myeloid-derived suppressor cells in the tumor environment is a target for cancer immunotherapy
Cook K, Xue W, Symonds P, Daniels I, Gijon M, Boocock D, et al.
J Immunother Cancer . 2021 Jul; 9(7). PMID: 34321274
Background: Homocitrullination is the post-translational modification of lysine that is recognized by T cells. Methods: This study identified homocitrullinated peptides from aldolase, enolase, cytokeratin and binding immunoglobulin protein and used...
6.
Combination vaccine based on citrullinated vimentin and enolase peptides induces potent CD4-mediated anti-tumor responses
Brentville V, Metheringham R, Daniels I, Atabani S, Symonds P, Cook K, et al.
J Immunother Cancer . 2020 Jun; 8(1). PMID: 32561639
Background: Stress-induced post-translational modifications occur during autophagy and can result in generation of new epitopes and immune recognition. One such modification is the conversion of arginine to citrulline by peptidylarginine...
7.
Engineering the Human Fc Region Enables Direct Cell Killing by Cancer Glycan-Targeting Antibodies without the Need for Immune Effector Cells or Complement
Vankemmelbeke M, McIntosh R, Chua J, Kirk T, Daniels I, Patsalidou M, et al.
Cancer Res . 2020 Jun; 80(16):3399-3412. PMID: 32532823
Murine IgG3 glycan-targeting mAb often induces direct cell killing in the absence of immune effector cells or complement via a proinflammatory mechanism resembling oncotic necrosis. This cancer cell killing is...
8.
T cell repertoire to citrullinated self-peptides in healthy humans is not confined to the HLA-DR SE alleles; Targeting of citrullinated self-peptides presented by HLA-DP4 for tumour therapy
Brentville V, Symonds P, Cook K, Daniels I, Pitt T, Gijon M, et al.
Oncoimmunology . 2019 May; 8(5):e1576490. PMID: 31069134
Post-translational modifications are induced in stressed cells which cause them to be recognised by the system. One such modification is citrullination where the positive charged arginine is modified to a...
9.
Targeting gp100 and TRP-2 with a DNA vaccine: Incorporating T cell epitopes with a human IgG1 antibody induces potent T cell responses that are associated with favourable clinical outcome in a phase I/II trial
Patel P, Ottensmeier C, Mulatero C, Lorigan P, Plummer R, Pandha H, et al.
Oncoimmunology . 2018 Jun; 7(6):e1433516. PMID: 29872563
A DNA vaccine, SCIB1, incorporating two CD8 and two CD4 epitopes from TRP-2/gp100 was evaluated in patients with metastatic melanoma. Each patient received SCIB1 via intramuscular injection with electroporation. The...
10.
Citrullinated α-enolase is an effective target for anti-cancer immunity
Cook K, Daniels I, Symonds P, Pitt T, Gijon M, Xue W, et al.
Oncoimmunology . 2018 Jan; 7(2):e1390642. PMID: 29308319
Targeting post-translationally modified epitopes may provide a new strategy for generating tumor specific immune responses. Citrullination is the post-translational modification of arginine to citrulline catalyzed by peptidylarginine deaminase (PAD) enzymes....