Rachael A Vaubel
Overview
Explore the profile of Rachael A Vaubel including associated specialties, affiliations and a list of published articles.
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34
Citations
660
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Recent Articles
1.
Garcia D, Rathi S, Connors M, Grams M, Vaubel R, Bakken K, et al.
Mol Cancer Ther
. 2024 Nov;
24(2):299-309.
PMID: 39559836
Ataxia Telangiectasia-mutated (ATM) inhibitors are being developed as radiosensitizers to improve the antitumor effects of radiotherapy, but ATM inhibition can also radiosensitize normal tissues. Therefore, understanding the elevated risk of...
2.
Vizcaino M, Giannini C, Vaubel R, Nguyen A, Trejo-Lopez J, Raghunathan A, et al.
J Neuropathol Exp Neurol
. 2024 Jul;
83(12):1003-1009.
PMID: 39042515
Pleomorphic xanthoastrocytomas (PXAs) harbor CDKN2A homozygous deletion in >90% of cases, resulting in loss of p16 expression by immunohistochemistry. Considering the proximity of MTAP to CDKN2A and their frequent concurrent...
3.
Jain S, Griffith J, Porath K, Rathi S, Le J, Pasa T, et al.
Clin Cancer Res
. 2024 May;
30(15):3287-3297.
PMID: 38743766
Purpose: Antibody-drug conjugates (ADC) are targeted therapies with robust efficacy in solid cancers, and there is intense interest in using EGFR-specific ADCs to target EGFR-amplified glioblastoma (GBM). Given GBM's molecular...
4.
Vizcaino M, Giannini C, Lalich D, Nael A, Jenkins R, Tran Q, et al.
J Neuropathol Exp Neurol
. 2024 May;
83(6):416-424.
PMID: 38699943
Ganglioglioma (GG) with anaplasia (anaplastic ganglioglioma) is a rare and controversial diagnosis. When present, anaplasia involves the glial component of the tumor, either at presentation or at recurrence. To date,...
5.
Chen J, Laverty D, Talele S, Bale A, Carlson B, Porath K, et al.
Sci Transl Med
. 2024 Feb;
16(734):eadj5962.
PMID: 38354228
ATM is a key mediator of radiation response, and pharmacological inhibition of ATM is a rational strategy to radiosensitize tumors. AZD1390 is a brain-penetrant ATM inhibitor and a potent radiosensitizer....
6.
Zhang W, Vaubel R, Oh J, Mladek A, Talele S, Zhang W, et al.
Mol Cancer Ther
. 2023 Oct;
23(1):47-55.
PMID: 37828724
MDM2-p53 inhibition may be effective in glioblastoma (GBM). This study evaluates the pharmacokinetics/pharmacodynamics of BI-907828, a potent antagonist of MDM2, in GBM, and demonstrates a translational paradigm with a focus...
7.
Blood-brain barrier disruption defines the extracellular metabolome of live human high-grade gliomas
Riviere-Cazaux C, Carlstrom L, Rajani K, Munoz-Casabella A, Rahman M, Gharibi-Loron A, et al.
Commun Biol
. 2023 Jun;
6(1):653.
PMID: 37340056
The extracellular microenvironment modulates glioma behaviour. It remains unknown if blood-brain barrier disruption merely reflects or functionally supports glioma aggressiveness. We utilised intra-operative microdialysis to sample the extracellular metabolome of...
8.
Guerin J, Kaufmann T, Eckel L, Morris J, Vaubel R, Giannini C, et al.
Radiology
. 2023 May;
307(5):e221885.
PMID: 37191486
The fifth edition of the World Health Organization classification of tumors of the central nervous system (CNS), published in 2021, introduces major shifts in the classification of brain and spine...
9.
Yagnik K, Vakharia K, Vaubel R, Vizcaino M, Benson J, Daniels D, et al.
J Neurol Surg B Skull Base
. 2023 May;
84(3):272-280.
PMID: 37180870
Neurenteric cysts (NECs) are rare, congenital lesions lined by endodermal cell-derived columnar or cuboidal epithelium. Based on previous studies, gross total removal of the capsule has been presumed to be...
10.
Vaubel R, Kumar R, Weiskittel T, Jenkins S, Dasari S, Uhm J, et al.
Neurooncol Adv
. 2023 Feb;
5(1):vdad004.
PMID: 36845294
Background: Meningiomas are the most common primary central nervous system (CNS) tumor in adults and CNS World Health Organization grade 2 (atypical) meningiomas show an intermediate risk of recurrence/progression. Molecular...