R W Tsien
Overview
Explore the profile of R W Tsien including associated specialties, affiliations and a list of published articles.
Author names and details appear as published. Due to indexing inconsistencies, multiple individuals may share a name, and a single author may have variations. MedLuna displays this data as publicly available, without modification or verification
Snapshot
Snapshot
Articles
179
Citations
16589
Followers
0
Related Specialties
Related Specialties
Top 10 Co-Authors
Top 10 Co-Authors
Published In
Published In
Affiliations
Affiliations
Soon will be listed here.
Recent Articles
1.
Karayannis T, Au E, Patel J, Kruglikov I, Markx S, Delorme R, et al.
Nature
. 2014 May;
511(7508):236-40.
PMID: 24870235
Although considerable evidence suggests that the chemical synapse is a lynchpin underlying affective disorders, how molecular insults differentially affect specific synaptic connections remains poorly understood. For instance, Neurexin 1a and...
2.
Tsien R, Noble D
J Membr Biol
. 2013 Nov;
1(1):248-73.
PMID: 24174053
The kinetics of ionic current mechanisms in excitable membranes are analyzed. It is assumed that there are voltage-dependent reactions occurring in the membrane which are independent of the flow of...
3.
Pagani R, Song M, McEnery M, Qin N, Tsien R, Toro L, et al.
Neuroscience
. 2003 Dec;
123(1):75-85.
PMID: 14667443
Voltage-dependent calcium channels (VDCC) have a key role in neuronal function transforming the voltage signals into intracellular calcium signals. They are composed of the pore-forming alpha(1) and the regulatory alpha(2)delta,...
4.
Aravanis A, Pyle J, Harata N, Tsien R
Neuropharmacology
. 2003 Oct;
45(6):797-813.
PMID: 14529718
At synapses of the mammalian central nervous system, release of neurotransmitter occurs at rates transiently as high as 100 Hz, putting extreme demands on nerve terminals with only tens of...
5.
Aravanis A, Pyle J, Tsien R
Nature
. 2003 Jun;
423(6940):643-7.
PMID: 12789339
Vesicle fusion and recycling are particularly critical for ongoing neurotransmitter release in the small nerve terminals of the brain, which typically contain about 30 functional vesicles. However, the modes of...
6.
Mermelstein P, Deisseroth K, Dasgupta N, Isaksen A, Tsien R
Proc Natl Acad Sci U S A
. 2001 Dec;
98(26):15342-7.
PMID: 11742070
The neuronal nucleus plays a vital role in information processing, but whether it supports computational functions such as paired-pulse facilitation, comparable to synapses, is unclear. Ca(2+)-dependent movement of calmodulin (CaM)...
7.
Piedras-Renteria E, Watase K, HARATA N, Zhuchenko O, Zoghbi H, Lee C, et al.
J Neurosci
. 2001 Nov;
21(23):9185-93.
PMID: 11717352
The expansion of polyglutamine tracts encoded by CAG trinucleotide repeats is a common mutational mechanism in inherited neurodegenerative diseases. Spinocerebellar ataxia type 6 (SCA6), an autosomal dominant, progressive disease, arises...
8.
HARATA N, Ryan T, Smith S, Buchanan J, Tsien R
Proc Natl Acad Sci U S A
. 2001 Oct;
98(22):12748-53.
PMID: 11675506
Exo-endocytotic turnover of synaptic vesicles (SVs) at synapses between hippocampal neurons in culture was examined by electron microscopy (EM). We carried out photoconversion (PC) of the fluorescent endocytotic marker FM...
9.
HARATA N, Pyle J, Aravanis A, Mozhayeva M, Kavalali E, Tsien R
Trends Neurosci
. 2001 Oct;
24(11):637-43.
PMID: 11672807
The tiny nerve terminals of central synapses contain far fewer vesicles than preparations commonly used for analysis of neurosecretion. Photoconversion of vesicles rendered fluorescent with the dye FM1-43 directly identified...
10.
Pitt G, Zuhlke R, Hudmon A, Schulman H, Reuter H, Tsien R
J Biol Chem
. 2001 Jun;
276(33):30794-802.
PMID: 11408490
Ca(2+)-dependent inactivation (CDI) of L-type Ca(2+) channels plays a critical role in controlling Ca(2+) entry and downstream signal transduction in excitable cells. Ca(2+)-insensitive forms of calmodulin (CaM) act as dominant...