R S Slack
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Explore the profile of R S Slack including associated specialties, affiliations and a list of published articles.
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Articles
33
Citations
1082
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Recent Articles
1.
Thrush A, Antoun G, Nikpay M, Patten D, DeVlugt C, Mauger J, et al.
Int J Obes (Lond)
. 2017 Nov;
42(3):353-362.
PMID: 29151592
Background/objectives: Inter-individual variability in weight loss during obesity treatment is complex and poorly understood. Here we use whole body and tissue approaches to investigate fuel oxidation characteristics in skeletal muscle...
2.
Julian L, Liu Y, Pakenham C, Dugal-Tessier D, Ruzhynsky V, Bae S, et al.
Cell Death Differ
. 2015 Apr;
23(4):565-75.
PMID: 25909886
Cell cycle proteins are important regulators of diverse cell fate decisions, and in this capacity have pivotal roles in neurogenesis and brain development. The mechanisms by which cell cycle regulation...
3.
Svoboda D, Paquin A, Park D, Slack R
Dev Biol
. 2013 Sep;
384(1):101-13.
PMID: 24056077
Pocket proteins (pRb, p107 and p130) are well studied in their role of regulating cell cycle progression. Increasing evidence suggests that these proteins also control early differentiation and even later...
4.
Irrcher I, Aleyasin H, Seifert E, Hewitt S, Chhabra S, Phillips M, et al.
Hum Mol Genet
. 2010 Jul;
19(19):3734-46.
PMID: 20639397
Growing evidence highlights a role for mitochondrial dysfunction and oxidative stress as underlying contributors to Parkinson's disease (PD) pathogenesis. DJ-1 (PARK7) is a recently identified recessive familial PD gene. Its...
5.
Shah R, Selby S, Yokley B, Slack R, Hurley C, Posch P
Tissue Antigens
. 2009 Apr;
74(1):50-6.
PMID: 19392797
Cytokine single nucleotide polymorphisms and consequent production levels have been associated with acute graft-vs-host disease (aGVHD) development. The aim of this pilot study was to determine whether polymorphisms in tumor...
6.
Krailo M, Goldman S, Slack R, Davenport V, Morris E, Laver J, et al.
Ann Oncol
. 2002 May;
13(3):460-9.
PMID: 11996479
Background: The outcome of children with relapsed Wilms' tumor is poor, especially with poor-risk factors such as unfavorable histology, early recurrence, previous three-drug therapy, relapse not confined to lungs and...
7.
Crocker S, Lamba W, Smith P, Callaghan S, Slack R, Anisman H, et al.
Proc Natl Acad Sci U S A
. 2001 Nov;
98(23):13385-90.
PMID: 11687617
Expression of the transcription factor c-Jun is induced in neurons of the central nervous system (CNS) in response to injury. Mechanical transection of the nigrostriatal pathway at the medial forebrain...
8.
Fortin A, Cregan S, MacLaurin J, Kushwaha N, Hickman E, Thompson C, et al.
J Cell Biol
. 2001 Oct;
155(2):207-16.
PMID: 11591730
p53 is a transcriptional activator which has been implicated as a key regulator of neuronal cell death after acute injury. We have shown previously that p53-mediated neuronal cell death involves...
9.
Simpson M, MacLaurin J, Xu D, Ferguson K, Vanderluit J, Davoli M, et al.
J Neurosci
. 2001 Sep;
21(18):7089-98.
PMID: 11549719
The retinoblastoma tumor suppressor protein, pRb, is a key regulator of cell cycle and has been implicated in the terminal differentiation of neuronal cells. Mice nullizygous for pRb die by...
10.
Morris E, Keramaris E, Rideout H, Slack R, Dyson N, Stefanis L, et al.
J Neurosci
. 2001 Jul;
21(14):5017-26.
PMID: 11438577
DNA damage has been implicated as one important initiator of cell death in neuropathological conditions such as stroke. Accordingly, it is important to understand the signaling processes that control neuronal...