R S Slack
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Explore the profile of R S Slack including associated specialties, affiliations and a list of published articles.
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33
Citations
1082
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Recent Articles
11.
Ferguson K, Slack R
Neuroreport
. 2001 Jul;
12(9):A55-62.
PMID: 11435948
Cell division during embryogenesis plays a crucial role in the formation of the nervous system. During this developmental process, proliferating neural precursor cells commit to a neuronal fate and, as...
12.
OSUGA H, Osuga S, Wang F, Fetni R, Hogan M, Slack R, et al.
Proc Natl Acad Sci U S A
. 2000 Aug;
97(18):10254-9.
PMID: 10944192
Cyclin-dependent kinases (CDKs) are commonly known to regulate cell proliferation. However, previous reports suggest that in cultured postmitotic neurons, activation of CDKs is a signal for death rather than cell...
13.
Cregan S, MacLaurin J, Gendron T, Callaghan S, Park D, Parks R, et al.
Gene Ther
. 2000 Aug;
7(14):1200-9.
PMID: 10918488
Recombinant adenovirus vectors have provided a major advance in gene delivery systems for post-mitotic neurons. However, the use of these first generation vectors has been limited due to the onset...
14.
Ferguson K, Callaghan S, OHare M, Park D, Slack R
J Biol Chem
. 2000 Aug;
275(43):33593-600.
PMID: 10915795
The tumor suppressor, retinoblastoma (Rb), is involved in both terminal mitosis and neuronal differentiation. We hypothesized that activation of the Rb pathway would induce cell cycle arrest in primary neural...
15.
OHare M, Hou S, Morris E, Cregan S, Xu Q, Slack R, et al.
J Biol Chem
. 2000 Jun;
275(33):25358-64.
PMID: 10851232
Growing evidence suggests that certain cell cycle regulators also mediate neuronal death. Of relevance, cyclin D1-associated kinase activity is increased and the retinoblastoma protein (Rb), a substrate of the cyclin...
16.
Keramaris E, Stefanis L, MacLaurin J, Harada N, Takaku K, Ishikawa T, et al.
Mol Cell Neurosci
. 2000 Jun;
15(4):368-79.
PMID: 10845773
Previous reports have shown that DNA-damage-evoked death of embryonic cortical neurons is delayed by general caspase inhibitors and is accompanied by an increase in DEVD-AFC cleavage activity. We show here...
17.
Giovanni A, Keramaris E, Morris E, Hou S, OHare M, Dyson N, et al.
J Biol Chem
. 2000 Apr;
275(16):11553-60.
PMID: 10766769
Although B-amyloid (AB) is suggested to play an important role in Alzheimer's disease, the mechanisms that control AB-evoked toxicity are unclear. We demonstrated previously that the cell cycle-related cyclin-dependent kinase...
18.
Hanfelt J, Slack R, Gehan E
Control Clin Trials
. 1999 Dec;
20(6):555-66.
PMID: 10588296
We present a modification to Simon's optimal design for phase II trials in which the objective is to minimize the median sample size rather than the expected sample size when...
19.
Cregan S, MacLaurin J, Craig C, Robertson G, Nicholson D, Park D, et al.
J Neurosci
. 1999 Sep;
19(18):7860-9.
PMID: 10479688
p53 is a pivotal molecule regulating the death of neurons both after acute injury and during development. The molecular mechanisms by which p53 induces apoptosis in neuronal cells, however, are...
20.
Callaghan D, Dong L, Callaghan S, Hou Y, Dagnino L, Slack R
Dev Biol
. 1999 Mar;
207(2):257-70.
PMID: 10068462
The severe neurological deficit in embryos carrying null mutations for the retinoblastoma (Rb) gene suggests that Rb plays a crucial role in neurogenesis. While developing neurons undergo apoptosis in vivo...